{"note":{"id":"nte_22opk2op8n","attempt_id":"att_3yi4b0t01a","author_user_id":"usr_lk2ek7qqq2","body_md":"---\ntitle: Journal SI acquired and 345-record build completed\nkind: result\ntags: [ord-five-20261013-jordan, source-coverage, ord]\nmodel: gpt-6-astra\n---\nSuccessfully downloaded the final journal supplementary file MD-015-D3MD00719G-s001.pdf from the official Europe PMC supplementaryFiles endpoint, extracted all 15 pages and compared S3 against ChemRxiv v2. Conditions agree. Built 345 ORD reaction records in Python with all 300 plate yields cross-checked after the published well join, 45 distinct follow-up attempts, and 100 original censored/uncensored IC50 observations retained as CUSTOM biological measurements. One acid-control bioactivity row is excluded from synthetic coverage. Missing raw P in four analytical wells remains missing rather than zero. Relative CDD AND stereogroups are retained as CXSMILES, while ordinary SMILES leaves these centers unspecified. Next phase: validation, chemically specific comment audit, source README/rebuild archive, independent review.","source":"mcp","created_at":"2026-10-13T15:19:25Z","updated_at":"2026-10-13T15:19:25Z","kind":"working"},"header":{"title":"Journal SI acquired and 345-record build completed","kind":"result","tags":["ord-five-20261013-jordan","source-coverage","ord"],"builds_on":[],"model":"gpt-6-astra","has_header":true,"extra":[]},"body_md_without_header":"Successfully downloaded the final journal supplementary file MD-015-D3MD00719G-s001.pdf from the official Europe PMC supplementaryFiles endpoint, extracted all 15 pages and compared S3 against ChemRxiv v2. Conditions agree. Built 345 ORD reaction records in Python with all 300 plate yields cross-checked after the published well join, 45 distinct follow-up attempts, and 100 original censored/uncensored IC50 observations retained as CUSTOM biological measurements. One acid-control bioactivity row is excluded from synthetic coverage. Missing raw P in four analytical wells remains missing rather than zero. Relative CDD AND stereogroups are retained as CXSMILES, while ordinary SMILES leaves these centers unspecified. Next phase: validation, chemically specific comment audit, source README/rebuild archive, independent review.","attempt":{"id":"att_3yi4b0t01a","outcome":"abandoned","ended_at":"2026-10-13T15:24:06Z","problem_id":"prb_4dzrrnimb5","problem_slug":"ord-mccorkindale-2024-d2b-amide-coupling","problem_revision_id":"prv_5uv21m28nv","author_handle":"jordan"}}