{
  "source": "ORD Dataset Wishlist",
  "snapshot_date": "2026-09-25",
  "ord_wishlist_status_at_snapshot": "Available",
  "ord_wishlist_card": "https://github.com/orgs/open-reaction-database/projects/11?pane=issue&itemId=126570090",
  "ord_data_issue": null,
  "title": "Exploring Homogeneous Conditions for Mild Buchwald–Hartwig Amination in Batch and Flow",
  "doi": "10.1021/acs.oprd.0c00018",
  "journal": "OPRD",
  "publication_date": "2020-02-11",
  "authors": [
    "Saeed K. Kashani",
    "Jacob E. Jessiman",
    "Stephen G. Newman"
  ],
  "article_open_access": {
    "status": "closed",
    "license": null
  },
  "dataset_size_estimate": 480,
  "experiment_type": null,
  "ord_priority": null,
  "ord_difficulty": null,
  "source_data_kind": "author_request_needed",
  "smiles_in_source": "unknown",
  "needs_author_contact": true,
  "data_locations": [
    {
      "url": "https://doi.org/10.1021/acs.oprd.0c00018",
      "what": "OPRD article and ACS-hosted SI (screening results as charts)",
      "license": "Closed access (publisher TDM/STM policies only)"
    },
    {
      "url": "https://doi.org/10.26434/chemrxiv.10094048.v2",
      "what": "ChemRxiv preprint (v1/v2) and its SI; may carry the same charts",
      "license": "unknown (ChemRxiv page blocked automated fetch)"
    }
  ],
  "notes": "Source: Kashani, Jessiman and Newman, Org. Process Res. Dev. 2020, doi:10.1021/acs.oprd.0c00018 (closed access; ChemRxiv preprint doi:10.26434/chemrxiv.10094048). About 480 Buchwald-Hartwig amination experiments exploring homogeneous (soluble-base) conditions in batch and flow. The SI shows the screening results only as charts. Tabulated values would need to be requested from the authors; reading values off plots is not recommended. Pitfalls: batch and flow runs need different setups (flow residence time and temperature). The chemistry spans many ligand, base and solvent combinations, so reagent identities must be mapped carefully.",
  "verification_caveats": "Data currently only in charts (low extractability, digitization error). Mixed batch and continuous-flow experiments. Screening-level yields; analysis method per experiment to be confirmed."
}