{
  "source": "ORD Dataset Wishlist",
  "snapshot_date": "2026-09-25",
  "ord_wishlist_status_at_snapshot": "Available",
  "ord_wishlist_card": "https://github.com/orgs/open-reaction-database/projects/11?pane=issue&itemId=126801408",
  "ord_data_issue": null,
  "title": "Using High-Throughput Iridium-Catalyzed C─H Borylations for Rapid Investigation of Heterocyclic Fragments in Discovery Chemistry",
  "doi": "10.1002/hlca.202500096",
  "journal": "Helvetica",
  "publication_date": "2025-08-14",
  "authors": [
    "Clara Muller",
    "Simone L. Kuhn",
    "Sharon Bell",
    "Richard L. Kraus",
    "Thomas Stadelmann",
    "Tomáš Šmejkal",
    "Julien C. Vantourout",
    "Daria Grosheva"
  ],
  "article_open_access": {
    "status": "closed",
    "license": null
  },
  "dataset_size_estimate": null,
  "experiment_type": "HTE",
  "ord_priority": "Low",
  "ord_difficulty": "Hard",
  "source_data_kind": "author_request_needed",
  "smiles_in_source": "no",
  "needs_author_contact": true,
  "data_locations": [
    {
      "url": "https://doi.org/10.1002/hlca.202500096",
      "what": "Wiley Helvetica Chimica Acta article plus SI (closed access). Not fetched because Wiley blocks automated access",
      "license": "Wiley standard terms (Crossref: termsAndConditions#vor)"
    }
  ],
  "notes": "High-throughput Ir-catalyzed C-H borylation of heterocyclic fragments for discovery chemistry (Syngenta). The article is closed access. Its SI gives the HTE method as images and descriptive text, and the ORD curator found no reaction outcome data there. Results may be in the paywalled article figures. A complete, reusable dataset would likely need to come from the authors. Dataset size is not recorded on the wishlist card. Cite DOI 10.1002/hlca.202500096.",
  "verification_caveats": "Regioselectivity outcomes (multiple borylation sites per heterocycle) need multiple product entries per reaction. HTE outcomes may be LCAP or MS-based rather than yields. Size unknown."
}