{
  "source": "ORD Dataset Wishlist",
  "snapshot_date": "2026-09-25",
  "ord_wishlist_status_at_snapshot": "Available",
  "ord_wishlist_card": "https://github.com/orgs/open-reaction-database/projects/11?pane=issue&itemId=126852582",
  "ord_data_issue": null,
  "title": "Expedited Aminoglutarimide C-N Cross-Coupling Enabled by High-Throughput Experimentation",
  "doi": "10.26434/chemrxiv-2024-1skr0",
  "journal": "JOC",
  "publication_date": "2024-11-15",
  "authors": [
    "Jacqueline W. Gu",
    "Martins S. Oderinde",
    "Hui Li",
    "F. E. ROBERTS",
    "Jacob M. Ganley",
    "Maximilian D. Palkowitz"
  ],
  "article_open_access": {
    "status": "green",
    "license": "cc-by-nc"
  },
  "dataset_size_estimate": 96,
  "experiment_type": "HTE",
  "ord_priority": "Medium",
  "ord_difficulty": "Hard",
  "source_data_kind": "plate_images_or_heatmaps",
  "smiles_in_source": "no",
  "needs_author_contact": false,
  "data_locations": [
    {
      "url": "https://chemrxiv.org/engage/chemrxiv/article-details/66c8b048a4e53c48765f6dfa",
      "what": "ChemRxiv preprint + SI (table image of LC area % for a 96-well screen; ligands shown as named structure images). The ChemRxiv site/API returned a bot challenge, so the SI was not inspected.",
      "license": "CC-BY-NC 4.0 (preprint, per Crossref)"
    },
    {
      "url": "https://doi.org/10.1021/acs.joc.4c02536",
      "what": "J. Org. Chem. version of record (ACS). Not fetched.",
      "license": "ACS standard (closed; Crossref lists only TDM/STM policy licenses)"
    }
  ],
  "notes": "Aminoglutarimide C-N cross-coupling (BMS), a 96-reaction HTE screen. Source data is in the ChemRxiv preprint SI (CC-BY-NC 4.0; the JOC version of record is ACS, closed). Outcomes are given as an image of a table of LC area percentages. A bubble plot in the SI appears to show the same data, so use it to cross-check the transcription. Ligands appear as named structure images, so their SMILES must be drawn or looked up and verified. Record LC area % as an area-percent measurement, not a yield. Cite the JOC DOI (10.1021/acs.joc.4c02536) and note the preprint DOI (10.26434/chemrxiv-2024-1skr0). The source files cannot be rehosted under CC-BY-NC, so the Problem should reference them by link only.",
  "verification_caveats": "Values are transcribed from an image, so transcription errors are likely without double-entry or a cross-check against the bubble plot. Outcomes are LC area %, not isolated or assay yields. Ligand identities are resolved from images and names. The pages were bot-blocked, so the SI layout was not confirmed."
}