{
  "source": "ORD Dataset Wishlist",
  "snapshot_date": "2026-09-25",
  "ord_wishlist_status_at_snapshot": "Available",
  "ord_wishlist_card": "https://github.com/orgs/open-reaction-database/projects/11?pane=issue&itemId=126570071",
  "ord_data_issue": null,
  "title": "High-Throughput Reaction Screening with Nanomoles of Solid Reagents Coated on Glass Beads",
  "doi": "10.1002/anie.201900536",
  "journal": "ACIE",
  "publication_date": "2019-03-20",
  "authors": [
    "Noah P. Tu",
    "Amanda W. Dombrowski",
    "Gashaw M. Goshu",
    "Anil Kumar Vasudevan",
    "Stevan W. Djurić",
    "Ying Wang"
  ],
  "article_open_access": {
    "status": "closed",
    "license": null
  },
  "dataset_size_estimate": null,
  "experiment_type": null,
  "ord_priority": null,
  "ord_difficulty": null,
  "source_data_kind": "unknown",
  "smiles_in_source": "unknown",
  "needs_author_contact": false,
  "data_locations": [
    {
      "url": "https://doi.org/10.1002/anie.201900536",
      "what": "Angew. Chem. Int. Ed. 2019, 58, 7987-7991 article and Supporting Information (not inspected; Wiley blocks bots)",
      "license": "Wiley publisher copyright (closed access; Crossref lists Wiley terms and conditions only)"
    },
    {
      "url": "https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=DOI:%2210.1002/anie.201900536%22&format=json",
      "what": "Europe PMC record (PMID 30891860). Not in PMC and no free full text.",
      "license": "n/a (metadata)"
    }
  ],
  "notes": "Angew. Chem. Int. Ed. 2019, 58, 7987-7991 (DOI 10.1002/anie.201900536). Introduces ChemBeads: glass beads coated with solid reagents (catalysts, bases, ligands) that deliver nanomole amounts of solids for high-throughput reaction screening, validated with 'preferred screening sets' of conditions. The article is closed access. The location and format of the screening results (figures, heatmaps or SI tables) have not been confirmed. Check the Wiley SI first. Pitfalls: reagents are delivered as coated beads at a nominal loading (wt %), so the amounts dispensed must be recorded carefully, and screening outcomes are probably LC/MS-based conversions or product ratios rather than isolated yields.",
  "verification_caveats": "Reagent amounts are nominal (bead mass times coating wt %), so ORD amounts must say how they were derived. Outcomes are probably semi-quantitative LC/MS area ratios or conversions. The paper may contain several unrelated demonstration screens (different reaction classes). Heatmap-only results would give approximate or binned values."
}