# Curate this paper into an ORD dataset

Build an Open Reaction Database (ORD) dataset of the reactions reported in:

- **Paper:** High-Throughput Reaction Screening with Nanomoles of Solid Reagents Coated on Glass Beads
- **Authors:** Noah P. Tu, Amanda W. Dombrowski, Gashaw M. Goshu et al.
- **Published:** ACIE, 2019-03-20
- **DOI:** [10.1002/anie.201900536](https://doi.org/10.1002/anie.201900536)
- **ORD wishlist card:** [open on GitHub](https://github.com/orgs/open-reaction-database/projects/11?pane=issue&itemId=126570071)

The reference input `card` holds these facts, the source-data locations and the notes below in machine-readable form.

## Scope

Every reaction the paper reports with its data: inputs with amounts and roles, conditions, workups, outcomes and provenance, following the `ord-curation` Skill. Submit one ORD Dataset for the paper; if its data come from several screens or methods, keep them together and say so in the dataset description.

## Source data

Angew. Chem. Int. Ed. 2019, 58, 7987-7991 (DOI 10.1002/anie.201900536). Introduces ChemBeads: glass beads coated with solid reagents (catalysts, bases, ligands) that deliver nanomole amounts of solids for high-throughput reaction screening, validated with 'preferred screening sets' of conditions. The article is closed access. The location and format of the screening results (figures, heatmaps or SI tables) have not been confirmed. Check the Wiley SI first. Pitfalls: reagents are delivered as coated beads at a nominal loading (wt %), so the amounts dispensed must be recorded carefully, and screening outcomes are probably LC/MS-based conversions or product ratios rather than isolated yields.

Known locations:

- [https://doi.org/10.1002/anie.201900536](https://doi.org/10.1002/anie.201900536): Angew. Chem. Int. Ed. 2019, 58, 7987-7991 article and Supporting Information (not inspected; Wiley blocks bots) (license: Wiley publisher copyright (closed access; Crossref lists Wiley terms and conditions only))
- [https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=DOI:%2210.1002/anie.201900536%22&format=json](https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=DOI:%2210.1002/anie.201900536%22&format=json): Europe PMC record (PMID 30891860). Not in PMC and no free full text. (license: n/a (metadata))

## Pitfalls

Reagent amounts are nominal (bead mass times coating wt %), so ORD amounts must say how they were derived. Outcomes are probably semi-quantitative LC/MS area ratios or conversions. The paper may contain several unrelated demonstration screens (different reaction classes). Heatmap-only results would give approximate or binned values.

## Deliver

- `dataset`: the ORD Dataset, compressed (`.binpb.gz`, `.pb.gz`, `.txtpb.gz`, `.pbtxt.gz` or `.parquet`), citing the DOI above in every reaction's provenance, with no dataset or reaction IDs.
- `sources`: a `.zip` with a `README.md` (which tables or files each part came from, how structures were checked), the template and spreadsheet or the script or notebook that rebuild the dataset, and `validation.txt`, the output of ORD's validator (ord-schema 0.8.3) on the `dataset` file.

## Before you start

Open the wishlist card. If it is no longer Available, someone has reserved or started it: coordinate with them or choose another paper. Get the source data only through legitimate channels (the publisher's Supporting Information, the repositories above, or the authors). Submitting the finished dataset to ORD, and ORD's separate Dataset Rewards program, follow ORD's own rules.