{
  "source": "ORD Dataset Wishlist",
  "snapshot_date": "2026-09-25",
  "ord_wishlist_status_at_snapshot": "Available",
  "ord_wishlist_card": "https://github.com/orgs/open-reaction-database/projects/11?pane=issue&itemId=126569958",
  "ord_data_issue": null,
  "title": "Temperature-Controlled Photoreactors and ChemBeads as Key Technologies for Robust and Practical Photochemical HTE",
  "doi": "10.1021/acs.oprd.3c00061",
  "journal": "OPRD",
  "publication_date": "2023-04-13",
  "authors": [
    "Paolo Piacentini",
    "James M. Fordham",
    "Eloísa Serrano",
    "Luca Hepp",
    "Marco Santagostino"
  ],
  "article_open_access": {
    "status": "closed",
    "license": null
  },
  "dataset_size_estimate": null,
  "experiment_type": "HTE, photochemistry, chembeads",
  "ord_priority": null,
  "ord_difficulty": null,
  "source_data_kind": "si_pdf_tables",
  "smiles_in_source": "no",
  "needs_author_contact": false,
  "data_locations": [
    {
      "url": "https://doi.org/10.1021/acs.oprd.3c00061",
      "what": "Article plus one SI file (Crossref component 10.1021/acs.oprd.3c00061.s001; format and contents not inspected, pubs.acs.org returns 403)",
      "license": "ACS standard (closed article; Crossref TDM policy only)"
    }
  ],
  "notes": "Org. Process Res. Dev. 2023, doi 10.1021/acs.oprd.3c00061. HTE photochemistry in temperature-controlled multiwell photoreactors, with photocatalysts dosed as ChemBeads. The setup was validated on five reaction classes chosen for their different sensitivity to oxygen, temperature and homogeneity. It was then applied to the scope of an Ir/Ni-co-catalysed visible-light C-N coupling of aryl halides with fluorinated amines, including a 100x scale-up on a PHIL flow/batch photoreactor. Crossref lists one SI file; its format and contents were not checked because ACS pages block automated access. Structures will have to be converted to SMILES from drawings or names. The closed-access SI cannot be re-hosted; cite and reference it only.",
  "verification_caveats": "Several reaction templates (five validation classes plus the C-N coupling), possibly best split into separate datasets. Plate results may be reported as heatmaps of conversion or area% rather than isolated yields. Photochemical conditions (wavelength, irradiance, reactor temperature) and ChemBead solid dosing need careful ORD encoding. The scale-up run may be under different conditions."
}