{
  "source": "ORD Dataset Wishlist",
  "snapshot_date": "2026-09-25",
  "ord_wishlist_status_at_snapshot": "Available",
  "ord_wishlist_card": "https://github.com/orgs/open-reaction-database/projects/11?pane=issue&itemId=126570064",
  "ord_data_issue": null,
  "title": "Development of a High-Throughput Kinetics Protocol and Application to an Aza-Michael Reaction",
  "doi": "10.1021/acs.oprd.1c00213",
  "journal": "OPRD",
  "publication_date": "2021-11-22",
  "authors": [
    "Li Xiao",
    "Anna L. Dunn"
  ],
  "article_open_access": {
    "status": "closed",
    "license": null
  },
  "dataset_size_estimate": null,
  "experiment_type": null,
  "ord_priority": null,
  "ord_difficulty": null,
  "source_data_kind": "author_request_needed",
  "smiles_in_source": "unknown",
  "needs_author_contact": true,
  "data_locations": [
    {
      "url": "https://doi.org/10.1021/acs.oprd.1c00213",
      "what": "OPRD article (2021) and Supporting Information; contents not verified",
      "license": "ACS publisher terms (closed article)"
    }
  ],
  "notes": "Paper: Xiao and Dunn, Org. Process Res. Dev. 2021, doi:10.1021/acs.oprd.1c00213 (closed access). It is a high-throughput kinetics protocol applied to an aza-Michael reaction. It is not confirmed whether the kinetic data (concentration or conversion against time for each condition) is published in tabular form. Check the SI first. If only plots are available, the time-course data has to be obtained from the authors or digitized, with the digitization clearly stated. Time-course measurements belong in ORD as ProductMeasurements on outcomes at multiple reaction times.",
  "verification_caveats": "Kinetic time-course data (many outcomes per reaction at different times) is harder to validate than single-endpoint yields. Values digitized from plots carry uncertainty that reviewers must judge. Enumerating an HTE kinetics plate may produce many near-duplicate reactions."
}