{
  "source": "ORD Dataset Wishlist",
  "snapshot_date": "2026-09-25",
  "ord_wishlist_status_at_snapshot": "Available",
  "ord_wishlist_card": "https://github.com/orgs/open-reaction-database/projects/11?pane=issue&itemId=127177359",
  "ord_data_issue": null,
  "title": "A Miniaturized Chemical High Throughput Experimentation Plate to Enable Late-Stage Oxidation Screening and Scale-up",
  "doi": "10.1021/acsmedchemlett.5c00175",
  "journal": "ACS Med Chem Lett",
  "publication_date": "2025-06-02",
  "authors": [
    "Javier Izquierdo",
    "Mary E. Bellizzi",
    "Noah P. Tu",
    "Andrew R. Bogdan",
    "Ying Wang"
  ],
  "article_open_access": {
    "status": "green",
    "license": null
  },
  "dataset_size_estimate": 96,
  "experiment_type": "HTE",
  "ord_priority": "High",
  "ord_difficulty": "Hard",
  "source_data_kind": "author_request_needed",
  "smiles_in_source": "unknown",
  "needs_author_contact": true,
  "data_locations": [
    {
      "url": "https://doi.org/10.1021/acsmedchemlett.5c00175",
      "what": "Journal article (ACS Med Chem Lett) and SI PDF. The SI has methods only; results may be in article figures",
      "license": "ACS publisher license (Crossref lists ACS policy URLs); not open"
    },
    {
      "url": "https://europepmc.org/articles/PMC12169457",
      "what": "Free-to-read copy in PMC (Europe PMC: inPMC=Y, isOpenAccess=N, hasSuppl=Y). No open full-text XML available",
      "license": "Not openly licensed"
    }
  ],
  "notes": "Source: ACS Med Chem Lett 10.1021/acsmedchemlett.5c00175 (AbbVie). Miniaturised 96-well HTE plate for late-stage oxidation screening, followed by scale-up. The SI PDF has experimental methods but not the per-well reaction data. Results appear only in the article, which is publisher-licensed. A free-to-read copy is in PMC (PMC12169457) but is not openly licensed. A complete dataset probably needs per-well data from the authors. Open for curation only once the data are obtainable.",
  "verification_caveats": "Late-stage oxidations often give several regioisomeric or over-oxidised products; product identities may be characterised only for scale-up hits. Screening outcomes may be relative LC-MS conversions shown as a heatmap rather than yields."
}