{
  "source": "ORD Dataset Wishlist",
  "snapshot_date": "2026-09-25",
  "ord_wishlist_status_at_snapshot": "Available",
  "ord_wishlist_card": "https://github.com/orgs/open-reaction-database/projects/11?pane=issue&itemId=126570072",
  "ord_data_issue": null,
  "title": "Synthesis of Proline Analogues via Rh-Catalyzed Asymmetric Conjugate Addition",
  "doi": "10.1021/acscatal.0c04648",
  "journal": "ACS Catalysis",
  "publication_date": "2020-12-31",
  "authors": [
    "Emma K. Edelstein",
    "Danica A. Rankic",
    "Caroline C. Dudley",
    "Spencer E. McMinn",
    "Donovon A. Adpressa"
  ],
  "article_open_access": {
    "status": "closed",
    "license": null
  },
  "dataset_size_estimate": null,
  "experiment_type": null,
  "ord_priority": null,
  "ord_difficulty": null,
  "source_data_kind": "si_pdf_tables",
  "smiles_in_source": "no",
  "needs_author_contact": false,
  "data_locations": [
    {
      "url": "https://doi.org/10.1021/acscatal.0c04648",
      "what": "Article plus one SI file (Crossref component 10.1021/acscatal.0c04648.s001; format and contents not inspected, pubs.acs.org returns 403)",
      "license": "ACS standard (closed article; Crossref TDM policy only)"
    }
  ],
  "notes": "ACS Catal. 2021 (issued online 2020-12-31), doi 10.1021/acscatal.0c04648. Enantio- and diastereoselective Rh-catalysed conjugate addition of aryl/vinyl boronic acids to dehydroproline electrophiles, giving 3-substituted proline analogues. An HTE campaign identified the chiral catalyst, followed by a substrate scope. Crossref lists one SI file; its format was not checked because ACS pages block automated access. Expect HTE screening results (ligand/metal/conditions vs. yield, dr and ee) as tables or heatmaps, plus scope entries with isolated yields and selectivities. SMILES must be drawn from structures or names. The closed-access SI cannot be re-hosted; cite and reference it only.",
  "verification_caveats": "Outcomes include diastereo- and enantioselectivity (dr, ee) alongside yield. HTE screen outcomes may be assay yields (HPLC/UPLC with internal standard) rather than isolated yields. Chiral ligands need correct stereo SMILES. Screen and scope may use different conditions."
}