{
  "source": "ORD Dataset Wishlist",
  "snapshot_date": "2026-09-25",
  "ord_wishlist_status_at_snapshot": "Available",
  "ord_wishlist_card": "https://github.com/orgs/open-reaction-database/projects/11?pane=issue&itemId=126570079",
  "ord_data_issue": null,
  "title": "Use of High-Throughput Tools for Telescoped Continuous Flow Synthesis of an Alkynylnaphthyridine Anticancer Agent, HSN608",
  "doi": "10.1021/acs.oprd.0c00289",
  "journal": "OPRD",
  "publication_date": "2020-10-06",
  "authors": [
    "Shruti A. Biyani",
    "Qingqing Qi",
    "Jingze Wu",
    "Yuta W. Moriuchi",
    "Elizabeth A. Larocque",
    "Herman O. Sintim",
    "David Hiram Thompson"
  ],
  "article_open_access": {
    "status": "closed",
    "license": null
  },
  "dataset_size_estimate": null,
  "experiment_type": null,
  "ord_priority": null,
  "ord_difficulty": null,
  "source_data_kind": "si_pdf_tables",
  "smiles_in_source": "no",
  "needs_author_contact": false,
  "data_locations": [
    {
      "url": "https://doi.org/10.1021/acs.oprd.0c00289",
      "what": "Article plus one SI file (Crossref component 10.1021/acs.oprd.0c00289.s001; format and contents not inspected, pubs.acs.org returns 403)",
      "license": "ACS standard (closed article; Crossref TDM policy only)"
    }
  ],
  "notes": "Org. Process Res. Dev. 2020, doi 10.1021/acs.oprd.0c00289. Route development for the alkynylnaphthyridine FLT3 inhibitor HSN608: HATU amidation and Sonogashira coupling optimised with DoE, HTE and DESI-MS high-throughput screening, then telescoped in continuous flow with 10-fold lower Pd and 5-fold lower Cu loading. Crossref lists one SI file; its format was not checked because ACS pages block automated access. Candidate datasets: (1) batch HTE/DoE screening of the two steps; (2) the telescoped flow runs. SMILES must be drawn from structures. The closed-access SI cannot be re-hosted; cite and reference it only.",
  "verification_caveats": "DESI-MS screening outcomes are relative MS ion intensities or ratios, not calibrated yields. Continuous-flow telescoped runs need flow-specific ORD encoding (residence time, flow rates, reactor volume) and may be transient. A single target product across many condition variations. DoE runs may be reported only as model or response-surface plots."
}