{
  "source": "ORD Dataset Wishlist",
  "snapshot_date": "2026-09-25",
  "ord_wishlist_status_at_snapshot": "Available",
  "ord_wishlist_card": "https://github.com/orgs/open-reaction-database/projects/11?pane=issue&itemId=126798874",
  "ord_data_issue": null,
  "title": "Automation of Multistep Reaction-Based Solid-Phase Synthesis Using Novel Polystyrene-Coated Magnetic Particles",
  "doi": "10.1002/chem.202501429",
  "journal": "ChemEurJ",
  "publication_date": "2025-08-11",
  "authors": [
    "Sascha Mueller",
    "Daniel J. Gosling",
    "Marco Palmieri",
    "Anne-Laure Le Goff",
    "Daniel L Meyer",
    "Peter J. Meier"
  ],
  "article_open_access": {
    "status": "bronze",
    "license": null
  },
  "dataset_size_estimate": 25,
  "experiment_type": "MTE",
  "ord_priority": "Low",
  "ord_difficulty": "Hard",
  "source_data_kind": "narrative_or_figures",
  "smiles_in_source": "no",
  "needs_author_contact": false,
  "data_locations": [
    {
      "url": "https://doi.org/10.1002/chem.202501429",
      "what": "Chem. Eur. J. 2025 article. By the ORD notes, its SI has narrative per-product descriptions with structure images. Not fetched because Wiley blocks bots. Europe PMC has PMID 40787775 and no PMC full text.",
      "license": "Wiley standard terms (free to read per OpenAlex 'bronze'; not openly licensed)"
    }
  ],
  "notes": "Source: the SI of Chem. Eur. J. 2025, 10.1002/chem.202501429. This is automated multistep solid-phase synthesis on polystyrene-coated magnetic particles, about 25 products. The SI gives each product as a structure image with a narrative description of the result. Turn this into per-reaction records: reagents, amounts, steps, conditions and outcomes, with SMILES made from the images. The article is free to read but not openly licensed, so treat the source as reference only.",
  "verification_caveats": "Multistep reactions on a solid support: resin- or particle-bound intermediates and linkers cannot be written as simple SMILES and may need a multistep or workup representation. Outcomes may be purity or yield after cleavage. Narrative descriptions may leave amounts or conditions implicit. Structures come from images."
}