{
  "source": "ORD Dataset Wishlist",
  "snapshot_date": "2026-09-25",
  "ord_wishlist_status_at_snapshot": "Available",
  "ord_wishlist_card": "https://github.com/orgs/open-reaction-database/projects/11?pane=issue&itemId=126570062",
  "ord_data_issue": null,
  "title": "cis-4-Alkoxydialkyl- and cis-4-Alkoxydiarylprolinol Organocatalysts: High Throughput Experimentation (HTE)-Based and Design of Experiments (DoE)-Guided Development of a Highly Enantioselective aza-Michael Addition of Cyclic Imides to α,β-Unsaturated Aldehydes",
  "doi": "10.1002/adsc.201700120",
  "journal": "Adv Synth Cat",
  "publication_date": "2017-04-06",
  "authors": [
    "Ismael Arenas",
    "Alessandro Ferrali",
    "Carles Rodríguez‐Escrich",
    "Fernando Bravo",
    "Miquel À. Pericàs"
  ],
  "article_open_access": {
    "status": "closed",
    "license": null
  },
  "dataset_size_estimate": null,
  "experiment_type": null,
  "ord_priority": null,
  "ord_difficulty": null,
  "source_data_kind": "si_pdf_tables",
  "smiles_in_source": "no",
  "needs_author_contact": false,
  "data_locations": [
    {
      "url": "https://doi.org/10.1002/adsc.201700120",
      "what": "Article and Wiley supporting information (not fetched; format and contents unknown)",
      "license": "Wiley standard terms (closed article)"
    }
  ],
  "notes": "Adv. Synth. Catal. 2017, doi 10.1002/adsc.201700120. A family of 37 cis-4-alkoxydialkyl/diarylprolinol organocatalysts was screened by HTE in the enantioselective aza-Michael addition of cyclic imides (succinimide, maleimide) to alpha,beta-unsaturated aldehydes. DoE then optimised conditions, and 12 adducts were made in the scope. Catalyst screening results (conversion/ee), DoE runs and scope yields/ee are expected in the article tables and the Wiley SI; formats not verified. Catalyst and product SMILES must be drawn from structures. The closed-access article and SI cannot be re-hosted; cite and reference them only.",
  "verification_caveats": "Outcomes include ee (and possibly conversion by NMR/GC) rather than isolated yield for the HTE screen. Catalyst structures are 37 bespoke compounds whose stereo SMILES need care. DoE runs may be reported only in aggregate or as model plots. Adducts may be isolated after in-situ reduction, which changes the product identity."
}