{
  "source": "ORD Dataset Wishlist",
  "snapshot_date": "2026-09-25",
  "ord_wishlist_status_at_snapshot": "Available",
  "ord_wishlist_card": "https://github.com/orgs/open-reaction-database/projects/11?pane=issue&itemId=126824886",
  "ord_data_issue": null,
  "title": "A Low-Yield Reaction Is Still a Result: A Study on Grignard Reagent Free Cobalt Catalyzed C(sp2)-H Arylation",
  "doi": "10.26434/chemrxiv-2025-qw468",
  "journal": "ChemRxiv",
  "publication_date": "2025-04-16",
  "authors": [
    "N. Narayanan",
    "Laurent Lefort",
    "Maëva Mercier",
    "Soufyan Jerhaoui",
    "Michael Schnürch"
  ],
  "article_open_access": {
    "status": "green",
    "license": "cc-by-nc-nd"
  },
  "dataset_size_estimate": 250,
  "experiment_type": "HTE",
  "ord_priority": "High",
  "ord_difficulty": "Normal",
  "source_data_kind": "si_pdf_tables",
  "smiles_in_source": "partial",
  "needs_author_contact": false,
  "data_locations": [
    {
      "url": "https://doi.org/10.26434/chemrxiv-2025-qw468",
      "what": "ChemRxiv preprint. Main text and SI are in one PDF with HTE result tables; later SI pages list SMILES for some chemicals",
      "license": "CC-BY-NC-ND 4.0 (per Crossref)"
    }
  ],
  "notes": "Source: ChemRxiv preprint 10.26434/chemrxiv-2025-qw468 (cobalt-catalysed C(sp2)-H arylation without Grignard reagents; Janssen / TU Wien). About 250 HTE reactions. The reaction data are tables in the SI, which is in the same PDF as the main article. A SMILES list for some chemicals appears later in the SI; the remaining reagents must be converted from names or structures to SMILES. Many results are low-yield or negative, and these are the point of the dataset, so record zero and low yields explicitly and do not drop them. The preprint is CC-BY-NC-ND 4.0. Crossref shows no journal version yet. If one appears, check whether the data changed and cite the version you used.",
  "verification_caveats": "Outcomes are mostly low or zero yields, so check that ORD outcomes represent failed reactions correctly (product with yield 0, analysis method stated). Data must be transcribed from PDF tables, which risks row/column errors, so spot-checking against the PDF is needed. Only some chemicals have SMILES; the rest need name-to-structure conversion, which is error-prone for catalysts and ligands. The yield type (GC, NMR or isolated) must be taken from the SI text."
}