{
  "source": "ORD Dataset Wishlist",
  "snapshot_date": "2026-09-25",
  "ord_wishlist_status_at_snapshot": "Available",
  "ord_wishlist_card": "https://github.com/orgs/open-reaction-database/projects/11?pane=issue&itemId=132986716",
  "ord_data_issue": null,
  "title": "Synthesis of Anti-β-Hydroxytryptophans by Asymmetric Transfer Hydrogenation via Dynamic Kinetic Resolution",
  "doi": "10.1021/acs.joc.5c01849",
  "journal": "JOC",
  "publication_date": "2025-09-26",
  "authors": [
    "Scott R. Pollack",
    "Michael R. Berwanger",
    "S. Pailloux"
  ],
  "article_open_access": {
    "status": "closed",
    "license": null
  },
  "dataset_size_estimate": 144,
  "experiment_type": "HTE",
  "ord_priority": "Medium",
  "ord_difficulty": "Hard",
  "source_data_kind": "si_pdf_tables",
  "smiles_in_source": "no",
  "needs_author_contact": false,
  "data_locations": [
    {
      "url": "https://doi.org/10.1021/acs.joc.5c01849",
      "what": "J. Org. Chem. 2025 article. By the ORD notes, its SI PDF contains the HTE screening tables. Not fetched because ACS blocks bots. Europe PMC has PMID 41001713 and no PMC full text.",
      "license": "ACS standard terms (article closed access; Crossref TDM/VOR policies)"
    }
  ],
  "notes": "Source: the SI of J. Org. Chem. 2025, 10.1021/acs.joc.5c01849. The HTE data (about 144 reactions, asymmetric transfer hydrogenation with dynamic kinetic resolution) is in PDF tables. The tables need cleanup into one row per reaction. SMILES must be made for substrates, catalysts/ligands, hydrogen donors and products. The article is closed access and the SI is under ACS terms, so treat the source as reference only.",
  "verification_caveats": "Outcomes probably include conversion, diastereomeric ratio (anti/syn) and enantioselectivity, which need correct stereo-aware product SMILES and ORD selectivity encoding. Catalyst/ligand identities in the screening tables may be given as abbreviations that must be resolved. SI accessibility was not confirmed."
}