{
  "source": "ORD Dataset Wishlist",
  "snapshot_date": "2026-09-25",
  "ord_wishlist_status_at_snapshot": "Available",
  "ord_wishlist_card": "https://github.com/orgs/open-reaction-database/projects/11?pane=issue&itemId=126570021",
  "ord_data_issue": null,
  "title": "Manufacturing Process Development for the Biaryl Ether Fragment of Nemtabrutinib (MK-1026)",
  "doi": "10.1021/acs.oprd.3c00218",
  "journal": "Organic Process Research & Development",
  "publication_date": "2023-10-24",
  "authors": [
    "Nicholas R. Deprez",
    "Harrison B. Rose",
    "Byron K. Peters",
    "Anthony Diaz-Santana",
    "Zhuqing Liu",
    "Nadine Kuhl",
    "Cheol Keun Chung",
    "Zhu Liu",
    "Justin A. Newman",
    "James Corry",
    "Erik D. Guetschow",
    "Erik Hoyt"
  ],
  "article_open_access": {
    "status": "closed",
    "license": null
  },
  "dataset_size_estimate": null,
  "experiment_type": null,
  "ord_priority": null,
  "ord_difficulty": null,
  "source_data_kind": "narrative_or_figures",
  "smiles_in_source": "no",
  "needs_author_contact": false,
  "data_locations": [
    {
      "url": "https://api.figshare.com/v2/articles/24431156",
      "what": "ACS SI PDF op3c00218_si_001.pdf (1.1 MB); contents not inspected",
      "license": "Labeled CC BY-NC 4.0 on figshare (ACS SI mirror); not verified against ACS terms"
    },
    {
      "url": "https://doi.org/10.1021/acs.oprd.3c00218",
      "what": "OPRD 2023 article (closed access)",
      "license": "ACS standard (closed)"
    }
  ],
  "notes": "Source: Deprez et al., Org. Process Res. Dev. 2023 (doi:10.1021/acs.oprd.3c00218). Manufacturing process development for the biaryl ether fragment of nemtabrutinib (MK-1026). The abstract mentions HTE in the development, but the amount of HTE data and its format are not confirmed. The article is closed-access. One SI PDF (~1.1 MB) exists, with no machine-readable data file. Expect optimization tables and possibly screening heatmaps in the article, plus experimental procedures in the SI. Structures must be drawn from schemes, and no SMILES are provided.",
  "verification_caveats": "Mix of HTE screens (possibly heatmaps with assay yields/LCAP) and scaled process runs with isolated yields. The two may need separate datasets or careful outcome typing. Multi-step fragment synthesis, so different reaction types."
}