{
  "source": "ORD Dataset Wishlist",
  "snapshot_date": "2026-09-25",
  "ord_wishlist_status_at_snapshot": "Available",
  "ord_wishlist_card": "https://github.com/orgs/open-reaction-database/projects/11?pane=issue&itemId=126570094",
  "ord_data_issue": null,
  "title": "Reagent Design and Ligand Evolution for the Development of a Mild Copper-Catalyzed Hydroxylation Reaction",
  "doi": "10.1021/acs.orglett.7b01403",
  "journal": "Org Lett",
  "publication_date": "2017-05-18",
  "authors": [
    "Patrick S. Fier",
    "Kevin M. Maloney"
  ],
  "article_open_access": {
    "status": "closed",
    "license": null
  },
  "dataset_size_estimate": 384,
  "experiment_type": null,
  "ord_priority": null,
  "ord_difficulty": null,
  "source_data_kind": "si_pdf_tables",
  "smiles_in_source": "unknown",
  "needs_author_contact": false,
  "data_locations": [
    {
      "url": "https://doi.org/10.1021/acs.orglett.7b01403",
      "what": "Org. Lett. 2017 article and SI PDF with the screening data table (per ORD notes); not fetched.",
      "license": "closed article (ACS); SI licence unknown"
    }
  ],
  "notes": "Data source: the Supporting Information PDF of Org. Lett. 2017 (ACS). According to the ORD wishlist it has a data table of about 384 screening reactions for Cu-catalysed hydroxylation of aryl halides, which varied hydroxide-surrogate reagents and ligands. The article is not open access, and the SI must be downloaded manually from the ACS page. Ligands and reagents are likely drawn or coded in the SI, so they need converting to SMILES. Confirm the outcome type (assay yield, conversion or area %) before encoding.",
  "verification_caveats": "Screening table in PDF form. Reagent and ligand identities may be coded (e.g. L1-Lx) with structures only in figures. The outcome type is unverified."
}