{
  "source": "ORD Dataset Wishlist",
  "snapshot_date": "2026-09-25",
  "ord_wishlist_status_at_snapshot": "Available",
  "ord_wishlist_card": "https://github.com/orgs/open-reaction-database/projects/11?pane=issue&itemId=126570067",
  "ord_data_issue": null,
  "title": "A High-Throughput Approach to Discovery: Heck-Type Reactivity with Aldehydes",
  "doi": "10.1055/s-0037-1610161",
  "journal": "Synlett",
  "publication_date": "2018-06-12",
  "authors": [
    "Stephen G. Newman",
    "Jaya Kishore Vandavasi"
  ],
  "article_open_access": {
    "status": "closed",
    "license": null
  },
  "dataset_size_estimate": null,
  "experiment_type": null,
  "ord_priority": null,
  "ord_difficulty": null,
  "source_data_kind": "author_request_needed",
  "smiles_in_source": "unknown",
  "needs_author_contact": true,
  "data_locations": [
    {
      "url": "https://www.thieme-connect.de/products/ejournals/abstract/10.1055/s-0037-1610161",
      "what": "Thieme landing page and SI (returned a bot-check page; not inspected)",
      "license": "closed (Thieme)"
    }
  ],
  "notes": "This Synlett 2018 account covers high-throughput discovery of a carbonyl-Heck reaction: intermolecular coupling of organotriflates with aldehydes to give ketones. The article is paywalled (Thieme). An earlier ORD curation attempt could not obtain the underlying screening data, and the SI could not be inspected. The data will probably need to come from the authors. Pitfalls: an account/review-style article may summarise screens reported in more detail in primary papers, and the HTE results may be shown only as figures or heatmaps.",
  "verification_caveats": "Data availability and format are unknown. HTE screens may be shown only as plate heatmaps. The account may overlap with primary publications from the same group, which risks duplicate reactions in ORD."
}