{
  "source": "ORD Dataset Wishlist",
  "snapshot_date": "2026-09-25",
  "ord_wishlist_status_at_snapshot": "Available",
  "ord_wishlist_card": "https://github.com/orgs/open-reaction-database/projects/11?pane=issue&itemId=126570025",
  "ord_data_issue": null,
  "title": "Automated high throughput workflow for rapid implementation of immobilized enzymes in chemical process development",
  "doi": "10.1039/D3RE00704A",
  "journal": "Reaction Chemistry & Engineering",
  "publication_date": "2023-12-22",
  "authors": [
    "Lukas Schober",
    "Philippe Dreier",
    "Theo Peschke"
  ],
  "article_open_access": {
    "status": "closed",
    "license": null
  },
  "dataset_size_estimate": null,
  "experiment_type": null,
  "ord_priority": null,
  "ord_difficulty": null,
  "source_data_kind": "unknown",
  "smiles_in_source": "unknown",
  "needs_author_contact": false,
  "data_locations": [
    {
      "url": "https://doi.org/10.1039/D3RE00704A",
      "what": "Reaction Chemistry & Engineering article and ESI (automated HTE workflow for enzyme immobilization, Novartis)",
      "license": "RSC standard terms (closed; Crossref lists only RSC terms of use)"
    }
  ],
  "notes": "Source: Schober, Dreier and Peschke (Novartis), React. Chem. Eng. 2024, doi:10.1039/D3RE00704A. Topic: an automated high-throughput workflow for optimizing and developing immobilized enzymes for process chemistry. First confirm that the ESI contains per-experiment results (carrier or immobilization conditions and the resulting activity, conversion or yield of the biocatalytic reaction). Represent the enzyme and immobilization support as catalyst inputs with clear identifiers, and give substrate and product structures as SMILES. The data location and format are not yet confirmed.",
  "verification_caveats": "Heterogeneous biocatalysts (enzyme on carrier) are poorly captured by SMILES. Outcomes may be enzyme activity or loading, not reaction yields. Some experiments may be immobilization procedures rather than reactions, which ORD represents poorly."
}