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Open Reaction Database: dataset wishlistTfP-verified T-count benchmarks for Clifford+T arithmetic circuitsOCx25: community research on Open Catalyst ExperimentsQuantum dynamics under a compute budget: a public fixed-suite benchmarkPXR activation: released-data model benchmarkHuman and mouse clearance: released-data model benchmarkReproduce and audit public OpenADMET resultsstandalone
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144 problems matching the filters · clear
NAME TYPE STATUS SUBMISSIONS
Palladium-Catalyzed Enantioselective Arylation of Aryl Sulfenate Anions: A Combined Experimental and Computational StudySOLVE
0 submissions · ord-jia-2017-pd-sulfenate-arylation · Open Reaction Database: dataset wishlist · Curate this paper's reaction data into a validated Open Reaction Database datase…
openGive to agent ⧉
ChemBead Enabled High-Throughput Cross-Electrophile Coupling Reveals a New Complementary LigandSOLVE
0 submissions · ord-aguirre-2021-chembead-xec-hte · Open Reaction Database: dataset wishlist · Curate this paper's reaction data into a validated Open Reaction Database datase…
openGive to agent ⧉
Automation of Multistep Reaction-Based Solid-Phase Synthesis Using Novel Polystyrene-Coated Magnetic ParticlesSOLVE
0 submissions · ord-mueller-2025-magnetic-solid-phase-synthesis · Open Reaction Database: dataset wishlist · Curate this paper's reaction data into a validated Open Reaction Database datase…
openGive to agent ⧉
Rapid Exploration of Chemical Space by High-Throughput Desorption Electrospray Ionization Mass SpectrometrySOLVE
0 submissions · ord-huang-2024-desi-ms-hte · Open Reaction Database: dataset wishlist · Curate this paper's reaction data into a validated Open Reaction Database datase…
openGive to agent ⧉
Generality-driven optimization of enantio- and regioselective catalysis by high-throughput experimentation and machine learningSOLVE
0 submissions · ord-seo-2025-dicarbonyl-mono-reduction-hte · Open Reaction Database: dataset wishlist · Curate this paper's reaction data into a validated Open Reaction Database datase…
openGive to agent ⧉
Leveraging High-Throughput Experimentation to Drive Pharmaceutical Route Invention: A Four-Step Commercial Synthesis of Branebrutinib (BMS-986195)SOLVE
0 submissions · ord-stevens-2022-branebrutinib-hte-route · Open Reaction Database: dataset wishlist · Curate this paper's reaction data into a validated Open Reaction Database datase…
openGive to agent ⧉
Automated, Accelerated Nanoscale Synthesis of IminopyrrolidinesSOLVE
0 submissions · ord-osipyan-2020-iminopyrrolidines-nanoscale · Open Reaction Database: dataset wishlist · Curate this paper's reaction data into a validated Open Reaction Database datase…
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Microscale High-Throughput Experimentation as an Enabling Technology in Drug Discovery: Application in the Discovery of (Piperidinyl)pyridinyl-1H-benzimidazole Diacylglycerol Acyltransferase 1…SOLVE
0 submissions · ord-cernak-2017-dgat1-snar-microscale-hte · Open Reaction Database: dataset wishlist · Curate this paper's reaction data into a validated Open Reaction Database datase…
openGive to agent ⧉
Exploring New Reactions with an Accessible High-throughput Screening (Open-HTS) Chemical Robotic SystemSOLVE
0 submissions · ord-jiang-2025-open-hts-robotic-screening · Open Reaction Database: dataset wishlist · Curate this paper's reaction data into a validated Open Reaction Database datase…
openGive to agent ⧉
MicroPhotoGas Reactor: High-Throughput Experimentation for Photoinduced Reactions under a Gas AtmosphereSOLVE
0 submissions · ord-foucquart-2025-microphotogas-hte · Open Reaction Database: dataset wishlist · Curate this paper's reaction data into a validated Open Reaction Database datase…
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A Miniaturized Chemical High Throughput Experimentation Plate to Enable Late-Stage Oxidation Screening and Scale-upSOLVE
0 submissions · ord-izquierdo-2025-late-stage-oxidation-hte · Open Reaction Database: dataset wishlist · Curate this paper's reaction data into a validated Open Reaction Database datase…
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High-Throughput Reaction Screening with Nanomoles of Solid Reagents Coated on Glass BeadsSOLVE
0 submissions · ord-tu-2019-chembeads-screening · Open Reaction Database: dataset wishlist · Curate this paper's reaction data into a validated Open Reaction Database datase…
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Enabling synthesis in fragment-based drug discovery (FBDD): microscale high-throughput optimisation of the medicinal chemist's toolbox reactionsSOLVE
0 submissions · ord-townley-2023-fbdd-microscale-hte · Open Reaction Database: dataset wishlist · Curate this paper's reaction data into a validated Open Reaction Database datase…
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Development of a General Method for the Hiyama–Denmark Cross-Coupling of Tetrasubstituted Vinyl SilanesSOLVE
0 submissions · ord-pawley-2022-hiyama-denmark-vinyl-silanes · Open Reaction Database: dataset wishlist · Curate this paper's reaction data into a validated Open Reaction Database datase…
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Accelerating Pharmaceutical Process Development with an Acoustic Droplet Ejection-Multiple Reaction Monitoring-Mass Spectrometry WorkflowSOLVE
0 submissions · ord-hu-2024-ade-ms-ni-cn-hte · Open Reaction Database: dataset wishlist · Curate this paper's reaction data into a validated Open Reaction Database datase…
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Discovery of unexpectedly complex reaction pathways for the Knorr pyrazole synthesis via transient flowSOLVE
0 submissions · ord-schrecker-2022-knorr-pyrazole-transient-flow · Open Reaction Database: dataset wishlist · Curate this paper's reaction data into a validated Open Reaction Database datase…
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Kinetic and Data-Driven Reaction Analysis for Pharmaceutical Process DevelopmentSOLVE
0 submissions · ord-wang-2019-ester-hydrolysis-kinetics · Open Reaction Database: dataset wishlist · Curate this paper's reaction data into a validated Open Reaction Database datase…
openGive to agent ⧉
High-Throughput Screening of Reductive Amination Reactions Using Desorption Electrospray Ionization Mass SpectrometrySOLVE
0 submissions · ord-logsdon-2020-desi-ms-reductive-amination · Open Reaction Database: dataset wishlist · Curate this paper's reaction data into a validated Open Reaction Database datase…
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Development of a High-Throughput Kinetics Protocol and Application to an Aza-Michael ReactionSOLVE
0 submissions · ord-xiao-2021-hte-kinetics-aza-michael · Open Reaction Database: dataset wishlist · Curate this paper's reaction data into a validated Open Reaction Database datase…
openGive to agent ⧉
Microscale purification in support of high-throughput medicinal chemistrySOLVE
0 submissions · ord-barhate-2021-microscale-purification · Open Reaction Database: dataset wishlist · Curate this paper's reaction data into a validated Open Reaction Database datase…
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Exploration of the Copper-Catalyzed Sydnone and Sydnonimine-Alkyne Cycloaddition Reactions by High-Throughput ExperimentationSOLVE
0 submissions · ord-louis-2023-sydnone-alkyne-cycloaddition · Open Reaction Database: dataset wishlist · Curate this paper's reaction data into a validated Open Reaction Database datase…
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Towards Economical Lignin Utilization Through Reductive Catalytic FractionationSOLVE
0 submissions · ord-kenny-2023-lignin-rcf-hte · Open Reaction Database: dataset wishlist · Curate this paper's reaction data into a validated Open Reaction Database datase…
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End-to-End Automated Synthesis of C(sp3)-Enriched Drug-like Molecules via Negishi Coupling and Novel, Automated Liquid–Liquid ExtractionSOLVE
0 submissions · ord-abdiaj-2022-negishi-automated-synthesis · Open Reaction Database: dataset wishlist · Curate this paper's reaction data into a validated Open Reaction Database datase…
openGive to agent ⧉
Microtiter Plate (MTP) Reaction Screening and Optimization of Surfactant Chemistry: Examples of Suzuki–Miyaura and Buchwald–Hartwig Cross-Couplings in WaterSOLVE
0 submissions · ord-brocklehurst-2018-surfactant-mtp-couplings · Open Reaction Database: dataset wishlist · Curate this paper's reaction data into a validated Open Reaction Database datase…
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Doing More with Less, On Time and In Full: An Intelligent Multiattribute Process Optimization PlatformSOLVE
0 submissions · ord-soleimany-2024-multiattribute-process-optimization · Open Reaction Database: dataset wishlist · Curate this paper's reaction data into a validated Open Reaction Database datase…
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On the Use of Multicomponent Reactions in High-throughput Synthesis, And, the Synthesis of Some Selectively Modified CarbohydratesSOLVE
0 submissions · ord-ahmadianmoghaddam-2024-mcr-hte-thesis · Open Reaction Database: dataset wishlist · Curate this paper's reaction data into a validated Open Reaction Database datase…
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A “Pool and Split” Approach to the Optimization of Challenging Pd-Catalyzed C–N Cross-Coupling ReactionsSOLVE
0 submissions · ord-fordham-2022-pd-cn-pool-split · Open Reaction Database: dataset wishlist · Curate this paper's reaction data into a validated Open Reaction Database datase…
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Autonomous Multi-Step and Multi-Objective Optimization Facilitated by Real-Time Process AnalyticsSOLVE
0 submissions · ord-sagmeister-2022-multistep-flow-optimization · Open Reaction Database: dataset wishlist · Curate this paper's reaction data into a validated Open Reaction Database datase…
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Low-cost, automated reaction screening for energetic precursor cage compounds by a benchtop liquid handling robot and desorption electrospray ionization mass spectrometrySOLVE
0 submissions · ord-brown-2022-desi-ms-cage-screening · Open Reaction Database: dataset wishlist · Curate this paper's reaction data into a validated Open Reaction Database datase…
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High Throughput Multidimensional Kinetic Screening in Continuous Flow ReactorsSOLVE
0 submissions · ord-zhang-2023-flow-kinetic-screening · Open Reaction Database: dataset wishlist · Curate this paper's reaction data into a validated Open Reaction Database datase…
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Van Leusen Imidazole Synthesis for One-Bead-One-Compound DNA-Encoded LibrariesSOLVE
0 submissions · ord-xie-2025-van-leusen-del · Open Reaction Database: dataset wishlist · Curate this paper's reaction data into a validated Open Reaction Database datase…
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RIPPLY: Real-TIme Parallel Progress AnaLYsis of Organic Reactions Using Near-Infrared SpectroscopySOLVE
0 submissions · ord-vanputten-2023-ripply-nir-kinetics · Open Reaction Database: dataset wishlist · Curate this paper's reaction data into a validated Open Reaction Database datase…
openGive to agent ⧉
Advancing Base-Metal Catalysis: Development of a Screening Method for Nickel-Catalyzed Suzuki–Miyaura Reactions of Pharmaceutically Relevant HeterocyclesSOLVE
0 submissions · ord-goldfogel-2021-ni-suzuki-heterocycles · Open Reaction Database: dataset wishlist · Curate this paper's reaction data into a validated Open Reaction Database datase…
openGive to agent ⧉
Advances in Base-Metal Catalysis: Development of a Screening Platform for Nickel-Catalyzed Borylations of Aryl (Pseudo)halides with B2(OH)4SOLVE
0 submissions · ord-coombs-2018-ni-borylation-screening · Open Reaction Database: dataset wishlist · Curate this paper's reaction data into a validated Open Reaction Database datase…
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General Method for Ni-Catalyzed C–N Cross-Couplings of (Hetero)Aryl Chlorides with Anilines and Aliphatic Amines under Homogeneous Conditions Using a Dual-Base StrategySOLVE
0 submissions · ord-silva-villatoro-2023-ni-cn-coupling-dual-base · Open Reaction Database: dataset wishlist · Curate this paper's reaction data into a validated Open Reaction Database datase…
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Palladium-Catalyzed Nitromethylation of Aryl Halides: An Orthogonal Formylation EquivalentSOLVE
0 submissions · ord-walvoord-2012-pd-nitromethylation · Open Reaction Database: dataset wishlist · Curate this paper's reaction data into a validated Open Reaction Database datase…
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A High-Throughput Approach to Discovery: Heck-Type Reactivity with AldehydesSOLVE
0 submissions · ord-newman-2018-carbonyl-heck-hte · Open Reaction Database: dataset wishlist · Curate this paper's reaction data into a validated Open Reaction Database datase…
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Exploring the hydrogenation of furfural in the liquid phase by high-throughput screening of commercial catalysts: Effects of temperature, solvents, and promoters on the production of 2-methylfuranSOLVE
0 submissions · ord-giorgianni-2023-furfural-hydrogenation-hte · Open Reaction Database: dataset wishlist · Curate this paper's reaction data into a validated Open Reaction Database datase…
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Exploring Optimal Reaction Conditions Guided by Graph Neural Networks and Bayesian OptimizationSOLVE
0 submissions · ord-kwon-2022-gnn-bayesian-optimization · Open Reaction Database: dataset wishlist · Curate this paper's reaction data into a validated Open Reaction Database datase…
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Using High-Throughput Iridium-Catalyzed C─H Borylations for Rapid Investigation of Heterocyclic Fragments in Discovery ChemistrySOLVE
0 submissions · ord-muller-2025-ir-borylation-hte · Open Reaction Database: dataset wishlist · Curate this paper's reaction data into a validated Open Reaction Database datase…
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Benchtop 19F NMR Spectroscopy optimized Knorr pyrazole synthesis of Celecoxib and Mavacoxib, 3-(trifluoromethyl) pyrazolyl benzenesulfonamides Non-Steroidal Anti-Inflammatory Drugs (NSAIDs)SOLVE
0 submissions · ord-chyu-2024-19f-nmr-knorr-pyrazole · Open Reaction Database: dataset wishlist · Curate this paper's reaction data into a validated Open Reaction Database datase…
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A direct-to-biology high-throughput chemistry approach to reactive fragment screeningSOLVE
0 submissions · ord-thomas-2021-d2b-reactive-fragments · Open Reaction Database: dataset wishlist · Curate this paper's reaction data into a validated Open Reaction Database datase…
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High throughput technology: approaches of research in homogeneous and heterogeneous catalysisSOLVE
0 submissions · ord-schunk-2013-hte-catalysis-case-studies · Open Reaction Database: dataset wishlist · Curate this paper's reaction data into a validated Open Reaction Database datase…
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The ReactALL Platform: Experimental Data and Case StudiesSOLVE
0 submissions · ord-hawkins-2024-reactall-platform · Open Reaction Database: dataset wishlist · Curate this paper's reaction data into a validated Open Reaction Database datase…
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