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Open Reaction Database: dataset wishlistTfP-verified T-count benchmarks for Clifford+T arithmetic circuitsOCx25: community research on Open Catalyst ExperimentsQuantum dynamics under a compute budget: a public fixed-suite benchmarkPXR activation: released-data model benchmarkHuman and mouse clearance: released-data model benchmarkReproduce and audit public OpenADMET resultsstandalone
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147 problems matching the filters · clear
NAME TYPE STATUS SUBMISSIONS
Accessing Diverse Azole Carboxylic Acid Building Blocks via Mild C–H Carboxylation: Parallel, One-Pot Amide Couplings and Machine-Learning-Guided Substrate Scope DesignSOLVE
0 submissions · ord-felten-2022-azole-ch-carboxylation-amide · Open Reaction Database: dataset wishlist · Curate this paper's reaction data into a validated Open Reaction Database datase…
openGive to agent ⧉
Thinking Outside the Library: Cluster Synthesis of Diverse Molecules on a Single Robotic PlatformSOLVE
0 submissions · ord-le-vaillant-2025-robotic-cluster-synthesis · Open Reaction Database: dataset wishlist · Curate this paper's reaction data into a validated Open Reaction Database datase…
openGive to agent ⧉
High-Throughput Photo- and Electrochemical sp2–sp3 Cross-Electrophile Coupling to Access Novel Tedizolid AnalogsSOLVE
0 submissions · ord-montero-bastidas-2023-tedizolid-xec · Open Reaction Database: dataset wishlist · Curate this paper's reaction data into a validated Open Reaction Database datase…
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Evaluating Predictive Accuracy in Asymmetric Catalysis: A Machine Learning Perspective on Local Reaction SpaceSOLVE
0 submissions · ord-betinol-2025-asymmetric-catalysis-literature · Open Reaction Database: dataset wishlist · Curate this paper's reaction data into a validated Open Reaction Database datase…
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Direct-to-Biology Accelerates PROTAC Synthesis and the Evaluation of Linker Effects on Permeability and DegradationSOLVE
0 submissions · ord-hendrick-2022-d2b-protac-synthesis · Open Reaction Database: dataset wishlist · Curate this paper's reaction data into a validated Open Reaction Database datase…
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Laboratory of the future: a modular flow platform with multiple integrated PAT tools for multistep reactionsSOLVE
0 submissions · ord-sagmeister-2019-flow-aldol-pat · Open Reaction Database: dataset wishlist · Curate this paper's reaction data into a validated Open Reaction Database datase…
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A low-volume flow electrochemical microreactor for rapid and automated process optimizationSOLVE
0 submissions · ord-rial-rodriguez-2023-flow-electrochem-optimisation · Open Reaction Database: dataset wishlist · Curate this paper's reaction data into a validated Open Reaction Database datase…
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Synthesis of Anti-β-Hydroxytryptophans by Asymmetric Transfer Hydrogenation via Dynamic Kinetic ResolutionSOLVE
0 submissions · ord-pollack-2025-hydroxytryptophan-ath-dkr · Open Reaction Database: dataset wishlist · Curate this paper's reaction data into a validated Open Reaction Database datase…
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High-throughput optimization of the C–H arylation of oxetanes via Ni/aldehyde photocatalysisSOLVE
0 submissions · ord-diccianni-2024-oxetane-c-h-arylation · Open Reaction Database: dataset wishlist · Curate this paper's reaction data into a validated Open Reaction Database datase…
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High-Throughput Optimization of a High-Pressure Catalytic ReactionSOLVE
0 submissions · ord-tanabe-2025-high-pressure-hydroformylation · Open Reaction Database: dataset wishlist · Curate this paper's reaction data into a validated Open Reaction Database datase…
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Reagent Design and Ligand Evolution for the Development of a Mild Copper-Catalyzed Hydroxylation ReactionSOLVE
0 submissions · ord-fier-2017-cu-hydroxylation · Open Reaction Database: dataset wishlist · Curate this paper's reaction data into a validated Open Reaction Database datase…
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Comprehensive Synthetic Route Redesign of AZD5991: A High-Complexity Atropisomeric MacrocycleSOLVE
0 submissions · ord-howell-2025-azd5991-route-redesign-hte · Open Reaction Database: dataset wishlist · Curate this paper's reaction data into a validated Open Reaction Database datase…
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Design and Application of a Screening Set for Monophosphine Ligands in Cross-CouplingSOLVE
0 submissions · ord-gensch-2022-monophosphine-screening-set · Open Reaction Database: dataset wishlist · Curate this paper's reaction data into a validated Open Reaction Database datase…
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Synthesis of Proline Analogues via Rh-Catalyzed Asymmetric Conjugate AdditionSOLVE
0 submissions · ord-edelstein-2020-rh-proline-analogues · Open Reaction Database: dataset wishlist · Curate this paper's reaction data into a validated Open Reaction Database datase…
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SuFEx Activation with Ca(NTf2)2: A Unified Strategy to Access Sulfamides, Sulfamates, and Sulfonamides from S(VI) FluoridesSOLVE
0 submissions · ord-mahapatra-2020-sufex-calcium-triflimide · Open Reaction Database: dataset wishlist · Curate this paper's reaction data into a validated Open Reaction Database datase…
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Selected Ion Monitoring Using Low-Cost Mass Spectrum Detectors Provides a Rapid, General, and Accurate Method for Enantiomeric Excess Determination in High-Throughput ExperimentationSOLVE
0 submissions · ord-korch-2022-sim-ms-ee-hte · Open Reaction Database: dataset wishlist · Curate this paper's reaction data into a validated Open Reaction Database datase…
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Cu Oxamate-Promoted Cross-Coupling of α-Branched Amines and Complex Aryl Halides: Investigating Ligand Function through Data ScienceSOLVE
0 submissions · ord-matthews-2023-cu-oxamate-amine-arylation · Open Reaction Database: dataset wishlist · Curate this paper's reaction data into a validated Open Reaction Database datase…
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Direct Heterocycle C–H Alkenylation via Dual Catalysis Using a Palladacycle Precatalyst: Multifactor Optimization and Scope Exploration Enabled by High-Throughput ExperimentationSOLVE
0 submissions · ord-pipaon-fernandez-2024-heterocycle-ch-alkenylation · Open Reaction Database: dataset wishlist · Curate this paper's reaction data into a validated Open Reaction Database datase…
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Enantioselective High-Throughput Assay Showcased for the Identification of (R)- as well as (S)-Selective Unspecific Peroxygenases for C−H OxidationSOLVE
0 submissions · ord-swoboda-2023-upo-enantioselective-assay · Open Reaction Database: dataset wishlist · Curate this paper's reaction data into a validated Open Reaction Database datase…
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Parallel Synthesis of 5’-Amino-5’-deoxy-adenosine Derivatives for Focused Chemical Space Exploration and their Application as Methyltransferase InhibitorsSOLVE
0 submissions · ord-hoba-2025-adenosine-amide-parallel-synthesis · Open Reaction Database: dataset wishlist · Curate this paper's reaction data into a validated Open Reaction Database datase…
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Temperature-Controlled Photoreactors and ChemBeads as Key Technologies for Robust and Practical Photochemical HTESOLVE
0 submissions · ord-piacentini-2023-photochem-hte-chembeads · Open Reaction Database: dataset wishlist · Curate this paper's reaction data into a validated Open Reaction Database datase…
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Nickel-catalyzed cross-coupling aminations via high-throughput mechanochemistry enabled by resonant acoustic mixingSOLVE
0 submissions · ord-nanni-2024-ni-amination-ram-mechanochem · Open Reaction Database: dataset wishlist · Curate this paper's reaction data into a validated Open Reaction Database datase…
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Data-Driven Multi-Objective Optimization Tactics for Catalytic Asymmetric Reactions Using Bisphosphine LigandsSOLVE
0 submissions · ord-dotson-2023-bisphosphine-asymmetric-hte · Open Reaction Database: dataset wishlist · Curate this paper's reaction data into a validated Open Reaction Database datase…
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Rapid Optimization of Photoredox Reactions for Continuous-Flow Systems Using Microscale Batch TechnologySOLVE
0 submissions · ord-gonzalez-esguevillas-2021-photoredox-flow-hte · Open Reaction Database: dataset wishlist · Curate this paper's reaction data into a validated Open Reaction Database datase…
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Alkene-Coordinated Palladium(0) Cross-Coupling Precatalysts: Comparing Oxidative Addition and Catalytic Reactivity for Dimethyl Fumarate and Maleic Anhydride Stabilizing LigandsSOLVE
0 submissions · ord-thomas-2024-pd-dmfu-precatalysts · Open Reaction Database: dataset wishlist · Curate this paper's reaction data into a validated Open Reaction Database datase…
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High-Throughput Approach toward the Development of a Mizoroki–Heck Reaction To Access Tricyclic SpirolactonesSOLVE
0 submissions · ord-annand-2020-mizoroki-heck-spirolactones · Open Reaction Database: dataset wishlist · Curate this paper's reaction data into a validated Open Reaction Database datase…
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Substrate-Photocatalyst Reactivity Matching Enables Broad Aryl Halide Scope in Light-Driven, Reductive Cross-Electrophile Coupling Using 13C NMR as a PredictorSOLVE
0 submissions · ord-chrisman-2025-photoredox-xec-aryl-halides · Open Reaction Database: dataset wishlist · Curate this paper's reaction data into a validated Open Reaction Database datase…
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High-Throughput Exploration of a Thioxanthone-catalyzed Photoredox C-O CouplingSOLVE
0 submissions · ord-andrews-2024-thioxanthone-photoredox-c-o · Open Reaction Database: dataset wishlist · Curate this paper's reaction data into a validated Open Reaction Database datase…
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Accelerating Cross-Modality Reaction Optimization via Robotically Automated Vacuum Enabled Direct-inject Mass Spectrometry (RAVE MS)SOLVE
0 submissions · ord-holland-moritz-2025-rave-ms-optimization · Open Reaction Database: dataset wishlist · Curate this paper's reaction data into a validated Open Reaction Database datase…
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High-throughput evaluation of in situ-generated cobalt(iii) catalysts for acyl fluoride synthesisSOLVE
0 submissions · ord-lee-2017-cobalt-acyl-fluoride-hte · Open Reaction Database: dataset wishlist · Curate this paper's reaction data into a validated Open Reaction Database datase…
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High-Throughput Automated Design of Experiment (DoE) and Kinetic Modeling to Aid in Process Development of an APISOLVE
0 submissions · ord-nunn-2017-doe-kinetic-api-process · Open Reaction Database: dataset wishlist · Curate this paper's reaction data into a validated Open Reaction Database datase…
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Bayesian Self-Optimization for Telescoped Continuous Flow SynthesisSOLVE
0 submissions · ord-clayton-2022-bayesian-telescoped-flow · Open Reaction Database: dataset wishlist · Curate this paper's reaction data into a validated Open Reaction Database datase…
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Developing Pharmaceutically Relevant Pd-Catalyzed C–N Coupling Reactivity Models Leveraging High-Throughput ExperimentationSOLVE
0 submissions · ord-ha-2025-pd-cn-coupling-hte · Open Reaction Database: dataset wishlist · Curate this paper's reaction data into a validated Open Reaction Database datase…
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Expedited Aminoglutarimide C-N Cross-Coupling Enabled by High-Throughput ExperimentationSOLVE
0 submissions · ord-gu-2024-aminoglutarimide-cn-coupling · Open Reaction Database: dataset wishlist · Curate this paper's reaction data into a validated Open Reaction Database datase…
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A Validated “Pool and Split” Approach to Screening and Optimization of Copper-Catalyzed C–N Cross-Coupling ReactionsSOLVE
0 submissions · ord-steimbach-2020-cu-cn-pool-split · Open Reaction Database: dataset wishlist · Curate this paper's reaction data into a validated Open Reaction Database datase…
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Manufacturing Process Development for the Biaryl Ether Fragment of Nemtabrutinib (MK-1026)SOLVE
0 submissions · ord-deprez-2023-nemtabrutinib-biaryl-ether · Open Reaction Database: dataset wishlist · Curate this paper's reaction data into a validated Open Reaction Database datase…
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‘Chemistry at the speed of sound’: automated 1536-well nanoscale synthesis of 16 scaffolds in parallelSOLVE
0 submissions · ord-gao-2023-acoustic-1536-well-mcr-synthesis · Open Reaction Database: dataset wishlist · Curate this paper's reaction data into a validated Open Reaction Database datase…
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Diversifying Amino Acids and Peptides via Deaminative Reductive Cross-Couplings Leveraging High-Throughput ExperimentationSOLVE
0 submissions · ord-twitty-2023-deaminative-reductive-coupling · Open Reaction Database: dataset wishlist · Curate this paper's reaction data into a validated Open Reaction Database datase…
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Photocatalytic Aminative Suzuki–Miyaura C(sp2)–N–C(sp3) Cross-CouplingSOLVE
0 submissions · ord-li-2025-photocatalytic-aminative-suzuki · Open Reaction Database: dataset wishlist · Curate this paper's reaction data into a validated Open Reaction Database datase…
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Integrated Direct-to-Biology Platform for the Nanoscale Synthesis and Biological Evaluation of PROTACsSOLVE
0 submissions · ord-stevens-2023-protac-direct-to-biology · Open Reaction Database: dataset wishlist · Curate this paper's reaction data into a validated Open Reaction Database datase…
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Integrating Catalysis and Analysis: Accelerated Asymmetric Reaction Development with a Multitasking Reactivity Umpolung/Chiroptical Reporter AuxiliarySOLVE
0 submissions · ord-kariapper-2025-chiroptical-michael-screen · Open Reaction Database: dataset wishlist · Curate this paper's reaction data into a validated Open Reaction Database datase…
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Use of High-Throughput Tools for Telescoped Continuous Flow Synthesis of an Alkynylnaphthyridine Anticancer Agent, HSN608SOLVE
0 submissions · ord-biyani-2020-hsn608-flow-hte · Open Reaction Database: dataset wishlist · Curate this paper's reaction data into a validated Open Reaction Database datase…
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Development of copper-catalyzed deaminative esterification using high-throughput experimentationSOLVE
0 submissions · ord-shen-2022-cu-deaminative-esterification · Open Reaction Database: dataset wishlist · Curate this paper's reaction data into a validated Open Reaction Database datase…
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Stereoconvergent and -divergent Synthesis of Tetrasubstituted Alkenes by Nickel-Catalyzed Cross-CouplingsSOLVE
0 submissions · ord-zell-2021-ni-tetrasubstituted-alkenes · Open Reaction Database: dataset wishlist · Curate this paper's reaction data into a validated Open Reaction Database datase…
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Unlocking the Potential of High-Throughput Experimentation for Electrochemistry with a Standardized Microscale ReactorSOLVE
0 submissions · ord-rein-2021-electrochemistry-hte-reactor · Open Reaction Database: dataset wishlist · Curate this paper's reaction data into a validated Open Reaction Database datase…
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cis-4-Alkoxydialkyl- and cis-4-Alkoxydiarylprolinol Organocatalysts: High Throughput Experimentation (HTE)-Based and Design of Experiments (DoE)-Guided Development of a Highly Enantioselective…SOLVE
0 submissions · ord-arenas-2017-prolinol-aza-michael · Open Reaction Database: dataset wishlist · Curate this paper's reaction data into a validated Open Reaction Database datase…
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Accelerated Development of a Scalable Ring-Closing Metathesis to Manufacture AMG 176 Using a Combined High-Throughput Experimentation and Computational Modeling ApproachSOLVE
0 submissions · ord-st-pierre-2020-amg176-rcm-hte · Open Reaction Database: dataset wishlist · Curate this paper's reaction data into a validated Open Reaction Database datase…
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Pharmaceutical diversification via palladium oxidative addition complexesSOLVE
0 submissions · ord-uehling-2019-pd-oac-diversification · Open Reaction Database: dataset wishlist · Curate this paper's reaction data into a validated Open Reaction Database datase…
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Optimizing Model Learning Performance on a Challenging Heck Reaction Yield Data SetSOLVE
0 submissions · ord-wang-2025-hecklit-heck-yields · Open Reaction Database: dataset wishlist · Curate this paper's reaction data into a validated Open Reaction Database datase…
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One-Pot Multisubstrate Screening for Asymmetric Catalysis Enabled by 19F NMR-Based Simultaneous Chiral AnalysisSOLVE
0 submissions · ord-kim-2025-19f-nmr-multisubstrate · Open Reaction Database: dataset wishlist · Curate this paper's reaction data into a validated Open Reaction Database datase…
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