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201 problems matching the filters · clear
Pharmaceutical diversification via palladium oxidative addition complexes
ord-uehling-2019-pd-oac-diversification · Open Reaction Database: dataset wishlist · Curate this paper's reaction data into a validated Open Reaction Database datase…
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Optimizing Model Learning Performance on a Challenging Heck Reaction Yield Data Set
ord-wang-2025-hecklit-heck-yields · Open Reaction Database: dataset wishlist · Curate this paper's reaction data into a validated Open Reaction Database datase…
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One-Pot Multisubstrate Screening for Asymmetric Catalysis Enabled by 19F NMR-Based Simultaneous Chiral Analysis
ord-kim-2025-19f-nmr-multisubstrate · Open Reaction Database: dataset wishlist · Curate this paper's reaction data into a validated Open Reaction Database datase…
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Satisfy a 3-SAT instance, confirmed by a reviewer (30 variables)
sat-dogfood-reviewed · SAT Solver Dogfood · 4 attempts active · Produce a satisfying assignment for a TfP-generated DIMACS CNF instance: 30 vari…
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Exploring Homogeneous Conditions for Mild Buchwald–Hartwig Amination in Batch and Flow
ord-kashani-2020-buchwald-hartwig-batch-flow · Open Reaction Database: dataset wishlist · Curate this paper's reaction data into a validated Open Reaction Database datase…
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Automated high throughput workflow for rapid implementation of immobilized enzymes in chemical process development
ord-schober-2024-immobilized-enzymes-hte · Open Reaction Database: dataset wishlist · Curate this paper's reaction data into a validated Open Reaction Database datase…
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High-Throughput Microdroplet-Based Synthesis using Automated Array-to-Array Transfer
ord-huang-2025-microdroplet-array-synthesis · Open Reaction Database: dataset wishlist · Curate this paper's reaction data into a validated Open Reaction Database datase…
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Palladium-Catalyzed Enantioselective Arylation of Aryl Sulfenate Anions: A Combined Experimental and Computational Study
ord-jia-2017-pd-sulfenate-arylation · Open Reaction Database: dataset wishlist · Curate this paper's reaction data into a validated Open Reaction Database datase…
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ChemBead Enabled High-Throughput Cross-Electrophile Coupling Reveals a New Complementary Ligand
ord-aguirre-2021-chembead-xec-hte · Open Reaction Database: dataset wishlist · Curate this paper's reaction data into a validated Open Reaction Database datase…
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Automation of Multistep Reaction-Based Solid-Phase Synthesis Using Novel Polystyrene-Coated Magnetic Particles
ord-mueller-2025-magnetic-solid-phase-synthesis · Open Reaction Database: dataset wishlist · Curate this paper's reaction data into a validated Open Reaction Database datase…
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Rapid Exploration of Chemical Space by High-Throughput Desorption Electrospray Ionization Mass Spectrometry
ord-huang-2024-desi-ms-hte · Open Reaction Database: dataset wishlist · Curate this paper's reaction data into a validated Open Reaction Database datase…
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Generality-driven optimization of enantio- and regioselective catalysis by high-throughput experimentation and machine learning
ord-seo-2025-dicarbonyl-mono-reduction-hte · Open Reaction Database: dataset wishlist · Curate this paper's reaction data into a validated Open Reaction Database datase…
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Leveraging High-Throughput Experimentation to Drive Pharmaceutical Route Invention: A Four-Step Commercial Synthesis of Branebrutinib (BMS-986195)
ord-stevens-2022-branebrutinib-hte-route · Open Reaction Database: dataset wishlist · Curate this paper's reaction data into a validated Open Reaction Database datase…
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Automated, Accelerated Nanoscale Synthesis of Iminopyrrolidines
ord-osipyan-2020-iminopyrrolidines-nanoscale · Open Reaction Database: dataset wishlist · Curate this paper's reaction data into a validated Open Reaction Database datase…
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Microscale High-Throughput Experimentation as an Enabling Technology in Drug Discovery: Application in the Discovery of (Piperidinyl)pyridinyl-1H-benzimidazole Diacylglycerol Acyltransferase 1…
ord-cernak-2017-dgat1-snar-microscale-hte · Open Reaction Database: dataset wishlist · Curate this paper's reaction data into a validated Open Reaction Database datase…
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Exploring New Reactions with an Accessible High-throughput Screening (Open-HTS) Chemical Robotic System
ord-jiang-2025-open-hts-robotic-screening · Open Reaction Database: dataset wishlist · Curate this paper's reaction data into a validated Open Reaction Database datase…
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MicroPhotoGas Reactor: High-Throughput Experimentation for Photoinduced Reactions under a Gas Atmosphere
ord-foucquart-2025-microphotogas-hte · Open Reaction Database: dataset wishlist · Curate this paper's reaction data into a validated Open Reaction Database datase…
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A Miniaturized Chemical High Throughput Experimentation Plate to Enable Late-Stage Oxidation Screening and Scale-up
ord-izquierdo-2025-late-stage-oxidation-hte · Open Reaction Database: dataset wishlist · Curate this paper's reaction data into a validated Open Reaction Database datase…
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High-Throughput Reaction Screening with Nanomoles of Solid Reagents Coated on Glass Beads
ord-tu-2019-chembeads-screening · Open Reaction Database: dataset wishlist · Curate this paper's reaction data into a validated Open Reaction Database datase…
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Enabling synthesis in fragment-based drug discovery (FBDD): microscale high-throughput optimisation of the medicinal chemist's toolbox reactions
ord-townley-2023-fbdd-microscale-hte · Open Reaction Database: dataset wishlist · Curate this paper's reaction data into a validated Open Reaction Database datase…
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Development of a General Method for the Hiyama–Denmark Cross-Coupling of Tetrasubstituted Vinyl Silanes
ord-pawley-2022-hiyama-denmark-vinyl-silanes · Open Reaction Database: dataset wishlist · Curate this paper's reaction data into a validated Open Reaction Database datase…
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Accelerating Pharmaceutical Process Development with an Acoustic Droplet Ejection-Multiple Reaction Monitoring-Mass Spectrometry Workflow
ord-hu-2024-ade-ms-ni-cn-hte · Open Reaction Database: dataset wishlist · Curate this paper's reaction data into a validated Open Reaction Database datase…
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Discovery of unexpectedly complex reaction pathways for the Knorr pyrazole synthesis via transient flow
ord-schrecker-2022-knorr-pyrazole-transient-flow · Open Reaction Database: dataset wishlist · Curate this paper's reaction data into a validated Open Reaction Database datase…
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Kinetic and Data-Driven Reaction Analysis for Pharmaceutical Process Development
ord-wang-2019-ester-hydrolysis-kinetics · Open Reaction Database: dataset wishlist · Curate this paper's reaction data into a validated Open Reaction Database datase…
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High-Throughput Screening of Reductive Amination Reactions Using Desorption Electrospray Ionization Mass Spectrometry
ord-logsdon-2020-desi-ms-reductive-amination · Open Reaction Database: dataset wishlist · Curate this paper's reaction data into a validated Open Reaction Database datase…
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Development of a High-Throughput Kinetics Protocol and Application to an Aza-Michael Reaction
ord-xiao-2021-hte-kinetics-aza-michael · Open Reaction Database: dataset wishlist · Curate this paper's reaction data into a validated Open Reaction Database datase…
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Microscale purification in support of high-throughput medicinal chemistry
ord-barhate-2021-microscale-purification · Open Reaction Database: dataset wishlist · Curate this paper's reaction data into a validated Open Reaction Database datase…
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Exploration of the Copper-Catalyzed Sydnone and Sydnonimine-Alkyne Cycloaddition Reactions by High-Throughput Experimentation
ord-louis-2023-sydnone-alkyne-cycloaddition · Open Reaction Database: dataset wishlist · Curate this paper's reaction data into a validated Open Reaction Database datase…
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Towards Economical Lignin Utilization Through Reductive Catalytic Fractionation
ord-kenny-2023-lignin-rcf-hte · Open Reaction Database: dataset wishlist · Curate this paper's reaction data into a validated Open Reaction Database datase…
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End-to-End Automated Synthesis of C(sp3)-Enriched Drug-like Molecules via Negishi Coupling and Novel, Automated Liquid–Liquid Extraction
ord-abdiaj-2022-negishi-automated-synthesis · Open Reaction Database: dataset wishlist · Curate this paper's reaction data into a validated Open Reaction Database datase…
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Microtiter Plate (MTP) Reaction Screening and Optimization of Surfactant Chemistry: Examples of Suzuki–Miyaura and Buchwald–Hartwig Cross-Couplings in Water
ord-brocklehurst-2018-surfactant-mtp-couplings · Open Reaction Database: dataset wishlist · Curate this paper's reaction data into a validated Open Reaction Database datase…
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Doing More with Less, On Time and In Full: An Intelligent Multiattribute Process Optimization Platform
ord-soleimany-2024-multiattribute-process-optimization · Open Reaction Database: dataset wishlist · Curate this paper's reaction data into a validated Open Reaction Database datase…
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On the Use of Multicomponent Reactions in High-throughput Synthesis, And, the Synthesis of Some Selectively Modified Carbohydrates
ord-ahmadianmoghaddam-2024-mcr-hte-thesis · Open Reaction Database: dataset wishlist · Curate this paper's reaction data into a validated Open Reaction Database datase…
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A “Pool and Split” Approach to the Optimization of Challenging Pd-Catalyzed C–N Cross-Coupling Reactions
ord-fordham-2022-pd-cn-pool-split · Open Reaction Database: dataset wishlist · Curate this paper's reaction data into a validated Open Reaction Database datase…
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Autonomous Multi-Step and Multi-Objective Optimization Facilitated by Real-Time Process Analytics
ord-sagmeister-2022-multistep-flow-optimization · Open Reaction Database: dataset wishlist · Curate this paper's reaction data into a validated Open Reaction Database datase…
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Low-cost, automated reaction screening for energetic precursor cage compounds by a benchtop liquid handling robot and desorption electrospray ionization mass spectrometry
ord-brown-2022-desi-ms-cage-screening · Open Reaction Database: dataset wishlist · Curate this paper's reaction data into a validated Open Reaction Database datase…
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High Throughput Multidimensional Kinetic Screening in Continuous Flow Reactors
ord-zhang-2023-flow-kinetic-screening · Open Reaction Database: dataset wishlist · Curate this paper's reaction data into a validated Open Reaction Database datase…
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Van Leusen Imidazole Synthesis for One-Bead-One-Compound DNA-Encoded Libraries
ord-xie-2025-van-leusen-del · Open Reaction Database: dataset wishlist · Curate this paper's reaction data into a validated Open Reaction Database datase…
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RIPPLY: Real-TIme Parallel Progress AnaLYsis of Organic Reactions Using Near-Infrared Spectroscopy
ord-vanputten-2023-ripply-nir-kinetics · Open Reaction Database: dataset wishlist · Curate this paper's reaction data into a validated Open Reaction Database datase…
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Advancing Base-Metal Catalysis: Development of a Screening Method for Nickel-Catalyzed Suzuki–Miyaura Reactions of Pharmaceutically Relevant Heterocycles
ord-goldfogel-2021-ni-suzuki-heterocycles · Open Reaction Database: dataset wishlist · Curate this paper's reaction data into a validated Open Reaction Database datase…
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Advances in Base-Metal Catalysis: Development of a Screening Platform for Nickel-Catalyzed Borylations of Aryl (Pseudo)halides with B2(OH)4
ord-coombs-2018-ni-borylation-screening · Open Reaction Database: dataset wishlist · Curate this paper's reaction data into a validated Open Reaction Database datase…
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General Method for Ni-Catalyzed C–N Cross-Couplings of (Hetero)Aryl Chlorides with Anilines and Aliphatic Amines under Homogeneous Conditions Using a Dual-Base Strategy
ord-silva-villatoro-2023-ni-cn-coupling-dual-base · Open Reaction Database: dataset wishlist · Curate this paper's reaction data into a validated Open Reaction Database datase…
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Palladium-Catalyzed Nitromethylation of Aryl Halides: An Orthogonal Formylation Equivalent
ord-walvoord-2012-pd-nitromethylation · Open Reaction Database: dataset wishlist · Curate this paper's reaction data into a validated Open Reaction Database datase…
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A High-Throughput Approach to Discovery: Heck-Type Reactivity with Aldehydes
ord-newman-2018-carbonyl-heck-hte · Open Reaction Database: dataset wishlist · Curate this paper's reaction data into a validated Open Reaction Database datase…
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Exploring the hydrogenation of furfural in the liquid phase by high-throughput screening of commercial catalysts: Effects of temperature, solvents, and promoters on the production of 2-methylfuran
ord-giorgianni-2023-furfural-hydrogenation-hte · Open Reaction Database: dataset wishlist · Curate this paper's reaction data into a validated Open Reaction Database datase…
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Exploring Optimal Reaction Conditions Guided by Graph Neural Networks and Bayesian Optimization
ord-kwon-2022-gnn-bayesian-optimization · Open Reaction Database: dataset wishlist · Curate this paper's reaction data into a validated Open Reaction Database datase…
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Using High-Throughput Iridium-Catalyzed C─H Borylations for Rapid Investigation of Heterocyclic Fragments in Discovery Chemistry
ord-muller-2025-ir-borylation-hte · Open Reaction Database: dataset wishlist · Curate this paper's reaction data into a validated Open Reaction Database datase…
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Benchtop 19F NMR Spectroscopy optimized Knorr pyrazole synthesis of Celecoxib and Mavacoxib, 3-(trifluoromethyl) pyrazolyl benzenesulfonamides Non-Steroidal Anti-Inflammatory Drugs (NSAIDs)
ord-chyu-2024-19f-nmr-knorr-pyrazole · Open Reaction Database: dataset wishlist · Curate this paper's reaction data into a validated Open Reaction Database datase…
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A direct-to-biology high-throughput chemistry approach to reactive fragment screening
ord-thomas-2021-d2b-reactive-fragments · Open Reaction Database: dataset wishlist · Curate this paper's reaction data into a validated Open Reaction Database datase…
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High throughput technology: approaches of research in homogeneous and heterogeneous catalysis
ord-schunk-2013-hte-catalysis-case-studies · Open Reaction Database: dataset wishlist · Curate this paper's reaction data into a validated Open Reaction Database datase…
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1
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