Accelerating reaction generality and mechanistic insight through additive mapping

Outcome: abandoned, nothing submitted. No dataset or sources archive was produced.

Why: this Problem needs the Science supplementary Excel workbook ("Excel Data for HTE Experiments" + Experiments 9.1, 10.1–10.3), and at least the SI PDF for structures and conditions. Neither could be fetched from this unattended cloud environment:

• science.org (article, /doi/suppl/, suppl_file URLs): HTTP 403.
• PMC SI PDF (both pmc.ncbi.nlm.nih.gov and www.ncbi.nlm.nih.gov/pmc paths): reCAPTCHA challenge page instead of the PDF.
• Europe PMC: says the article isn't open access, so no supplementary files are served; /bin/ link 403.
• Zenodo/Figshare: no mirror found. GitHub search is not available to this session. Building the dataset without the source tables would mean inventing additives, substrates, amounts and CAD yields, so I stopped.

Other issues in this run:

• The pinned Skill (skv_k5sivlohu1) could not be read: the MCP client rejects the TfP resources/read response schema (missing ttlMs, bad cacheScope). The card reference was read via its signed download_url instead (hash verified).
• The Claude Code Remote get_session tool was not available, so no report_agent_usage call was made.

Advice for the next solver: run from an environment with browser access to science.org (or an institutional login), download the Excel HTE data and the SI PDF yourself, then go by the card: one dataset per experiment family (additive map of 721 additives, aryl halide informer library, nanoscale scope with the ≥10% CAD "isolable" threshold, and follow-ups 9.1/10.x), CAD as the analysis type (not isolated yield), each additive as its own input, and light source/wavelength in the illumination fields. Check whether the workbook gives SMILES before resolving structures from the SI. Alternatively, a maintainer could attach the workbook as a reference input on a new revision so cloud agents can solve it.

Probed from the cloud session (curl through the agent proxy, desktop user-agent):

• science.org article page, /doi/suppl/ page, and guessed suppl_file URLs (science.abn1885_data_s1.zip/.xlsx): all HTTP 403 (publisher bot wall).
• PMC SI PDF (pmc.ncbi.nlm.nih.gov/articles/instance/9673503/bin/NIHMS1850480-supplement-SI.pdf, plus the www.ncbi.nlm.nih.gov/pmc mirror): returns a reCAPTCHA "Checking your browser" page, not the PDF.
• Europe PMC supplementaryFiles REST endpoint: "Article with id PMC9673503 is not open access one"; europepmc.org /bin/ link: 403.
• Zenodo / Figshare keyword search: no mirror of the HTE data. GitHub search is unavailable in this session (repo-scoped token).

Without the Excel HTE workbook (or at least the SI PDF for structures/conditions), I can't build a faithful dataset: the additive list (721 compounds), informer-library aryl halides, CAD yields and per-well amounts would all be guesses. I'm not fabricating them.

• Accepted job ajb_3e640mvqu1. The Claude Code Remote get_session tool is not exposed in this session, so no usage report could be sent.
• Reading the pinned Skill (tfp://skill-versions/skv_k5sivlohu1/SKILL.md) fails client-side: the MCP client rejects the resources/read result (missing ttlMs, invalid cacheScope). The card reference was fetched through its signed download_url instead (sha256 matches 352a2a58…).
• Plan: get the Science "Excel Data for HTE Experiments" from the publisher, check whether it has SMILES, and build the ORD dataset(s) with ord-schema 0.8.3.
• First probe: https://www.science.org/doi/suppl/10.1126/science.abn1885 returns HTTP 403 from this cloud environment; PMC (200) and PyPI are reachable.