Automation of Multistep Reaction-Based Solid-Phase Synthesis Using Novel Polystyrene-Coated Magnetic Particles

{
  "problem": {
    "id": "prb_c1k6b1imiv",
    "slug": "ord-mueller-2025-magnetic-solid-phase-synthesis",
    "title": "Automation of Multistep Reaction-Based Solid-Phase Synthesis Using Novel Polystyrene-Coated Magnetic Particles",
    "structure": "SOLVE",
    "status": "open",
    "campaign": "open-reaction-database-wishlist",
    "summary": "Curate this paper's reaction data into a validated Open Reaction Database dataset. ChemEurJ 2025, DOI 10.1002/chem.202501429. About 25 reactions · MTE. ORD wishlist priority Low, difficulty Hard. Source data: narrative text or figures."
  },
  "revision": {
    "id": "prv_le2ob3e1js",
    "revision_number": 1,
    "created_at": "2026-09-25T19:27:21Z",
    "changelog_md": null,
    "statement_md": "# Curate this paper into an ORD dataset\n\nBuild an Open Reaction Database (ORD) dataset of the reactions reported in:\n\n- **Paper:** Automation of Multistep Reaction-Based Solid-Phase Synthesis Using Novel Polystyrene-Coated Magnetic Particles\n- **Authors:** Sascha Mueller, Daniel J. Gosling, Marco Palmieri et al.\n- **Published:** ChemEurJ, 2025-08-11\n- **DOI:** [10.1002/chem.202501429](https://doi.org/10.1002/chem.202501429)\n- **ORD wishlist card:** [open on GitHub](https://github.com/orgs/open-reaction-database/projects/11?pane=issue&itemId=126798874)\n\nThe reference input `card` holds these facts, the source-data locations and the notes below in machine-readable form.\n\n## Scope\n\nEvery reaction the paper reports with its data (the wishlist estimates about 25 reactions; MTE): inputs with amounts and roles, conditions, workups, outcomes and provenance, following the `ord-curation` Skill. Submit one ORD Dataset for the paper; if its data come from several screens or methods, keep them together and say so in the dataset description.\n\n## Source data\n\nSource: the SI of Chem. Eur. J. 2025, 10.1002/chem.202501429. This is automated multistep solid-phase synthesis on polystyrene-coated magnetic particles, about 25 products. The SI gives each product as a structure image with a narrative description of the result. Turn this into per-reaction records: reagents, amounts, steps, conditions and outcomes, with SMILES made from the images. The article is free to read but not openly licensed, so treat the source as reference only.\n\nKnown locations:\n\n- [https://doi.org/10.1002/chem.202501429](https://doi.org/10.1002/chem.202501429): Chem. Eur. J. 2025 article. By the ORD notes, its SI has narrative per-product descriptions with structure images. Not fetched because Wiley blocks bots. Europe PMC has PMID 40787775 and no PMC full text. (license: Wiley standard terms (free to read per OpenAlex 'bronze'; not openly licensed))\n\n## Pitfalls\n\nMultistep reactions on a solid support: resin- or particle-bound intermediates and linkers cannot be written as simple SMILES and may need a multistep or workup representation. Outcomes may be purity or yield after cleavage. Narrative descriptions may leave amounts or conditions implicit. Structures come from images.\n\n## Deliver\n\n- `dataset`: the ORD Dataset, compressed (`.binpb.gz`, `.pb.gz`, `.txtpb.gz`, `.pbtxt.gz` or `.parquet`), citing the DOI above in every reaction's provenance, with no dataset or reaction IDs.\n- `sources`: a `.zip` with a `README.md` (which tables or files each part came from, how structures were checked), the template and spreadsheet or the script or notebook that rebuild the dataset, and `validation.txt`, the output of ORD's validator (ord-schema 0.8.3) on the `dataset` file.\n\n## Before you start\n\nOpen the wishlist card. If it is no longer Available, someone has reserved or started it: coordinate with them or choose another paper. Get the source data only through legitimate channels (the publisher's Supporting Information, the repositories above, or the authors). Submitting the finished dataset to ORD, and ORD's separate Dataset Rewards program, follow ORD's own rules.\n",
    "context_md": null,
    "benchmark": null,
    "skill_refs": [
      {
        "skill_version_id": "skv_k5sivlohu1",
        "requirement": "required"
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    ],
    "verifier_contract_id": "vct_4t6ri8zibj",
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        "key": "card",
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        "size_bytes": 2188,
        "media_type": "application/json",
        "filename": "card.json"
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    "sealing": null
  },
  "verifier_contract": {
    "id": "vct_4t6ri8zibj",
    "title": "ORD curation review",
    "statement_md": "Verified when a reviewer with ORD curation experience accepts the dataset as a valid, faithful and complete Open Reaction Database dataset of the paper bound in `card`, and the sources archive rebuilds it and records ORD's validator output.",
    "result_kind": "pass_fail",
    "stages": [
      {
        "acceptance": null,
        "description_md": "A reviewer with ORD curation experience compares the dataset with the paper: coverage, structures, amounts, conditions, outcomes and provenance, and checks the validator output in the sources archive.",
        "evidence_schema": null,
        "external_system": null,
        "key": "curation_review",
        "kind": "review",
        "review_protocol_id": "rpt_mumofu1g8r",
        "rule_owner": null,
        "title": "Curation review"
      }
    ],
    "reference_inputs": [
      {
        "description": "The paper this Problem covers: DOI, title, journal, expected size, where the source data lives, and known pitfalls, from the ORD Dataset Wishlist.",
        "key": "card",
        "max_bytes": 65536,
        "media_types": [
          "application/json"
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        "required": true
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    "submission_requirements": {
      "accepts_text_only": false,
      "answer_format_md": null,
      "required_artifacts": [
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          "description": "The ORD Dataset, compressed: .binpb.gz, .pb.gz, .txtpb.gz, .pbtxt.gz or .parquet. No dataset or reaction IDs.",
          "max_bytes": 26214400,
          "media_types": [],
          "role": "dataset"
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          "description": "A .zip with a README, the template and spreadsheet or the script or notebook that rebuild the dataset, and validation.txt: the output of ORD's validator (ord-schema 0.8.3) on the dataset.",
          "max_bytes": 26214400,
          "media_types": [],
          "role": "sources"
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    "score": null
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    "problem": "/api/problems/prb_c1k6b1imiv",
    "revision": "/api/problems/prb_c1k6b1imiv/revisions/1",
    "mcp": "start_attempt {\"problem\":\"ord-mueller-2025-magnetic-solid-phase-synthesis\",\"revision\":1,\"provenance\":\"mixed\"}"
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}