Preparation of 2-Heteroaryl-indolin-3-ones by Acid-Mediated Intramolecular Cyclization in Batch and Flow

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  "problem": {
    "id": "prb_jbzbo8kgav",
    "slug": "ord-saglam-2025-indolin-3-one-doe",
    "title": "Preparation of 2-Heteroaryl-indolin-3-ones by Acid-Mediated Intramolecular Cyclization in Batch and Flow",
    "structure": "SOLVE",
    "status": "open",
    "campaign": "open-reaction-database-wishlist",
    "summary": "Curate this paper's reaction data into a validated Open Reaction Database dataset. Org Lett 2025, DOI 10.1021/acs.orglett.5c00148. About 21 reactions · DOE. ORD wishlist priority Medium, difficulty Easy. Source data: tables in the Supporting Information PDF."
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    "created_at": "2026-09-25T19:27:21Z",
    "changelog_md": null,
    "statement_md": "# Curate this paper into an ORD dataset\n\nBuild an Open Reaction Database (ORD) dataset of the reactions reported in:\n\n- **Paper:** Preparation of 2-Heteroaryl-indolin-3-ones by Acid-Mediated Intramolecular Cyclization in Batch and Flow\n- **Authors:** Zeynep Saglam, Shu-Yu Liu, Yiding Chen et al.\n- **Published:** Org Lett, 2025-02-08\n- **DOI:** [10.1021/acs.orglett.5c00148](https://doi.org/10.1021/acs.orglett.5c00148)\n- **ORD wishlist card:** [open on GitHub](https://github.com/orgs/open-reaction-database/projects/11?pane=issue&itemId=126870725)\n\nThe reference input `card` holds these facts, the source-data locations and the notes below in machine-readable form.\n\n## Scope\n\nEvery reaction the paper reports with its data (the wishlist estimates about 21 reactions; DOE): inputs with amounts and roles, conditions, workups, outcomes and provenance, following the `ord-curation` Skill. Submit one ORD Dataset for the paper; if its data come from several screens or methods, keep them together and say so in the dataset description.\n\n## Source data\n\nSource: Saglam et al., Org. Lett. 2025, doi:10.1021/acs.orglett.5c00148. Acid-mediated intramolecular cyclisation to 2-heteroaryl-indolin-3-ones in batch and flow. The main target is a 21-run DOE campaign tabulated in the Supporting Information. The base, acid and solvent screens use a general method and can form a second dataset. The source has no SMILES, but few distinct species are involved, so assignment is quick. Record the DOE factor levels (e.g., temperature, equivalents, time, concentration) per run, and state which runs were batch and which were flow. The SI is ACS-hosted and not openly licensed. Cite it, but do not redistribute it.\n\nKnown locations:\n\n- [https://doi.org/10.1021/acs.orglett.5c00148](https://doi.org/10.1021/acs.orglett.5c00148): Org. Lett. article landing page and ACS-hosted SI PDF with the tabulated 21-run DOE and the base/acid/solvent screens (license: ACS publisher terms (closed article))\n\n## Pitfalls\n\nAny flow runs need flow-reactor representation (residence time, flow rates) in ORD, unlike the batch runs. The DOE response may be an assay yield or conversion by HPLC, whose method must be recorded. The screens and the DOE may be better split into two datasets.\n\n## Deliver\n\n- `dataset`: the ORD Dataset, compressed (`.binpb.gz`, `.pb.gz`, `.txtpb.gz`, `.pbtxt.gz` or `.parquet`), citing the DOI above in every reaction's provenance, with no dataset or reaction IDs.\n- `sources`: a `.zip` with a `README.md` (which tables or files each part came from, how structures were checked), the template and spreadsheet or the script or notebook that rebuild the dataset, and `validation.txt`, the output of ORD's validator (ord-schema 0.8.3) on the `dataset` file.\n\n## Before you start\n\nOpen the wishlist card. If it is no longer Available, someone has reserved or started it: coordinate with them or choose another paper. Get the source data only through legitimate channels (the publisher's Supporting Information, the repositories above, or the authors). Submitting the finished dataset to ORD, and ORD's separate Dataset Rewards program, follow ORD's own rules.\n",
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    "statement_md": "Verified when a reviewer with ORD curation experience accepts the dataset as a valid, faithful and complete Open Reaction Database dataset of the paper bound in `card`, and the sources archive rebuilds it and records ORD's validator output.",
    "result_kind": "pass_fail",
    "stages": [
      {
        "acceptance": null,
        "description_md": "A reviewer with ORD curation experience compares the dataset with the paper: coverage, structures, amounts, conditions, outcomes and provenance, and checks the validator output in the sources archive.",
        "evidence_schema": null,
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        "key": "curation_review",
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        "title": "Curation review"
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        "description": "The paper this Problem covers: DOI, title, journal, expected size, where the source data lives, and known pitfalls, from the ORD Dataset Wishlist.",
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