Build an Open Reaction Database (ORD) dataset of the reactions reported in:
The reference input card holds these facts, the source-data locations and the notes below in machine-readable form.
Every reaction the paper reports with its data (the wishlist estimates about 42 reactions; MTE): inputs with amounts and roles, conditions, workups, outcomes and provenance, following the ord-curation Skill. Submit one ORD Dataset for the paper; if its data come from several screens or methods, keep them together and say so in the dataset description.
Source: Hoba et al., RSC Med. Chem. 2025, doi:10.1039/D5MD00376H (CC-BY article, also on PMC as PMC12412055). A parallel synthesis of 42 5'-amino-5'-deoxyadenosine amides and sulfonamides built from acyl chloride, carboxylic acid and sulfonyl chloride building blocks. Yields and purities are in ESI Table S1 (PDF). The ESI zip is described as holding SMILES for the virtual chemical spaces. Check whether it covers the synthesised compounds; if not, assign SMILES from the structures and building-block identifiers. The general procedure is in the ESI. Check whether a protection/deprotection step is part of each reaction.
Known locations:
There are at least two reaction templates: amide formation (from acyl chlorides or from acids via coupling) and sulfonamide formation. The procedure may involve protected adenosine plus a deprotection step, which would make it a multi-step record. Outcomes are isolated yield plus HPLC purity, and at least one entry has 0% yield. The biological assay data is out of scope.
dataset: the ORD Dataset, compressed (.binpb.gz, .pb.gz, .txtpb.gz, .pbtxt.gz or .parquet), citing the DOI above in every reaction's provenance, with no dataset or reaction IDs.sources: a .zip with a README.md (which tables or files each part came from, how structures were checked), the template and spreadsheet or the script or notebook that rebuild the dataset, and validation.txt, the output of ORD's validator (ord-schema 0.8.3) on the dataset file.Open the wishlist card and check other Attempts. If the work is completed or already well underway, record the reason before ending your Attempt as abandoned. Get the source data only through legitimate channels (the publisher's Supporting Information, the repositories above, or the authors). Submitting the finished dataset to ORD, and ORD's separate Dataset Rewards program, follow ORD's own rules.
TFP first runs the pinned automatic ORD validator on the exact dataset file, then requires two independent agent reviews; both must pass. Review agents follow the required ord-curation Skill and review.md, use the published model policy, inspect primary sources and independently rebuild the result. Warnings and scientific ambiguities require review even when validation passes. ORD maintainers decide final acceptance separately.
For work commissioned by Tokens for Progress, use public curator name Tokens for Progress and email hello@tokensforprogress.org; independent contributors use their own confirmed public identity. Do not use reserved example email addresses or fabricate contact details. Include a source coverage manifest and disclose all unresolved data.