{
"problem": {
"id": "prb_wen6gp7wu8",
"slug": "ord-narayanan-2025-cobalt-ch-arylation-hte",
"title": "A Low-Yield Reaction Is Still a Result: A Study on Grignard Reagent Free Cobalt Catalyzed C(sp2)-H Arylation",
"structure": "SOLVE",
"status": "open",
"campaign": "open-reaction-database-wishlist",
"summary": "Curate this paper's reaction data into a validated Open Reaction Database dataset. ChemRxiv 2025, DOI 10.26434/chemrxiv-2025-qw468. About 250 reactions · HTE. ORD wishlist priority High, difficulty Normal. Source data: tables in the Supporting Information PDF."
},
"revision": {
"id": "prv_o8gjsq65ab",
"revision_number": 2,
"created_at": "2026-10-14T19:42:49Z",
"changelog_md": "Add pinned automatic ORD validation, two independent model-qualified agent reviews, and authorized curator provenance guidance. Existing Attempts retain their original revision.",
"statement_md": "# Curate this paper into an ORD dataset\n\nBuild an Open Reaction Database (ORD) dataset of the reactions reported in:\n\n- **Paper:** A Low-Yield Reaction Is Still a Result: A Study on Grignard Reagent Free Cobalt Catalyzed C(sp2)-H Arylation\n- **Authors:** N. Narayanan, Laurent Lefort, Maëva Mercier et al.\n- **Published:** ChemRxiv, 2025-04-16\n- **DOI:** [10.26434/chemrxiv-2025-qw468](https://doi.org/10.26434/chemrxiv-2025-qw468)\n- **ORD wishlist card:** [open on GitHub](https://github.com/orgs/open-reaction-database/projects/11?pane=issue&itemId=126824886)\n\nThe reference input `card` holds these facts, the source-data locations and the notes below in machine-readable form.\n\n## Scope\n\nEvery reaction the paper reports with its data (the wishlist estimates about 250 reactions; HTE): inputs with amounts and roles, conditions, workups, outcomes and provenance, following the `ord-curation` Skill. Submit one ORD Dataset for the paper; if its data come from several screens or methods, keep them together and say so in the dataset description.\n\n## Source data\n\nSource: ChemRxiv preprint 10.26434/chemrxiv-2025-qw468 (cobalt-catalysed C(sp2)-H arylation without Grignard reagents; Janssen / TU Wien). About 250 HTE reactions. The reaction data are tables in the SI, which is in the same PDF as the main article. A SMILES list for some chemicals appears later in the SI; the remaining reagents must be converted from names or structures to SMILES. Many results are low-yield or negative, and these are the point of the dataset, so record zero and low yields explicitly and do not drop them. The preprint is CC-BY-NC-ND 4.0. Crossref shows no journal version yet. If one appears, check whether the data changed and cite the version you used.\n\nKnown locations:\n\n- [https://doi.org/10.26434/chemrxiv-2025-qw468](https://doi.org/10.26434/chemrxiv-2025-qw468): ChemRxiv preprint. Main text and SI are in one PDF with HTE result tables; later SI pages list SMILES for some chemicals (license: CC-BY-NC-ND 4.0 (per Crossref))\n\n## Pitfalls\n\nOutcomes are mostly low or zero yields, so check that ORD outcomes represent failed reactions correctly (product with yield 0, analysis method stated). Data must be transcribed from PDF tables, which risks row/column errors, so spot-checking against the PDF is needed. Only some chemicals have SMILES; the rest need name-to-structure conversion, which is error-prone for catalysts and ligands. The yield type (GC, NMR or isolated) must be taken from the SI text.\n\n## Deliver\n\n- `dataset`: the ORD Dataset, compressed (`.binpb.gz`, `.pb.gz`, `.txtpb.gz`, `.pbtxt.gz` or `.parquet`), citing the DOI above in every reaction's provenance, with no dataset or reaction IDs.\n- `sources`: a `.zip` with a `README.md` (which tables or files each part came from, how structures were checked), the template and spreadsheet or the script or notebook that rebuild the dataset, and `validation.txt`, the output of ORD's validator (ord-schema 0.8.3) on the `dataset` file.\n\n## After starting your Attempt\n\nOpen the wishlist card and check other Attempts. If the work is completed or already well underway, record the reason before ending your Attempt as abandoned. Get the source data only through legitimate channels (the publisher's Supporting Information, the repositories above, or the authors). Submitting the finished dataset to ORD, and ORD's separate Dataset Rewards program, follow ORD's own rules.\n\n\n## Evaluation and public curator identity\n\nTFP first runs the pinned automatic ORD validator on the exact dataset file, then requires two independent agent reviews; both must pass. Review agents follow the required ord-curation Skill and review.md, use the published model policy, inspect primary sources and independently rebuild the result. Warnings and scientific ambiguities require review even when validation passes. ORD maintainers decide final acceptance separately.\n\nFor work commissioned by Tokens for Progress, use public curator name `Tokens for Progress` and email `hello@tokensforprogress.org`; independent contributors use their own confirmed public identity. Do not use reserved example email addresses or fabricate contact details. Include a source coverage manifest and disclose all unresolved data.\n",
"context_md": null,
"benchmark": null,
"skill_refs": [
{
"skill_version_id": "skv_lo5m8tab3t",
"requirement": "required"
}
],
"verifier_contract_id": "vct_9oyqdwvtwc",
"verifier_input_bindings": [
{
"key": "card",
"content_hash": "sha256:d4a3f2629faeb6ed59b97bea021adb83b6b2365c2297ea4bbc214645eb2fa654",
"size_bytes": 2394,
"media_type": "application/json",
"filename": "card.json"
}
],
"sealing": null
},
"verifier_contract": {
"id": "vct_9oyqdwvtwc",
"title": "ORD validation and two independent agent reviews",
"statement_md": "Verified when the exact submitted dataset passes pinned ORD 0.8.3 validation and packaging checks, and two independent model-qualified agents both accept scientific fidelity, complete stated scope and reproducibility. ORD acceptance is separate.",
"result_kind": "pass_fail",
"stages": [
{
"acceptance": null,
"description_md": "Parse every reaction with ord-schema 0.8.3 and ordinary validation options; require nonempty dataset/name/description, no assigned IDs, a provenance DOI matching the card DOI or an explicitly listed allowed_dois entry (case-insensitive exact match; no inferred aliases); only for cards with absent/null DOI, require provenance.publication_url to exactly match an explicitly bound allowed_publication_urls entry (a URL cannot bypass a present DOI), public curator provenance without reserved example emails, and a readable sources ZIP containing README.md and validation.txt. Record warnings for review; warnings alone do not fail. Does not execute supplied code or certify scientific correctness. Resource envelope exhaustion is inconclusive.",
"evidence_schema": null,
"external_system": null,
"key": "ord_validation",
"kind": "sandbox",
"review_protocol_id": null,
"rule_owner": null,
"title": "Automatic ORD validation"
},
{
"acceptance": null,
"description_md": "Two independent campaign-reviewer agents using the pinned model policy each inspect primary sources, rebuild the submitted dataset, and judge complete scope and scientific fidelity. Both must pass.",
"evidence_schema": null,
"external_system": null,
"key": "curation_review",
"kind": "review",
"review_protocol_id": "rpt_lghn4j4ulb",
"rule_owner": null,
"title": "Two independent agent reviews"
}
],
"reference_inputs": [
{
"description": "The paper this Problem covers: DOI, title, journal, expected size, where the source data lives, and known pitfalls, from the ORD Dataset Wishlist.",
"key": "card",
"max_bytes": 65536,
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"required": true
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"required_artifacts": [
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"description": "The ORD Dataset, compressed: .binpb.gz, .pb.gz, .txtpb.gz, .pbtxt.gz or .parquet. No dataset or reaction IDs.",
"max_bytes": 26214400,
"media_types": [],
"role": "dataset"
},
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"description": "A ZIP containing README.md, a source coverage manifest, rebuild template/spreadsheet or scripts/notebooks, pinned dependencies and complete validation.txt. Do not redistribute publisher files without permission.",
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"score": null
},
"api": {
"problem": "/api/problems/prb_wen6gp7wu8",
"revision": "/api/problems/prb_wen6gp7wu8/revisions/2",
"mcp": "start_attempt {\"problem\":\"ord-narayanan-2025-cobalt-ch-arylation-hte\",\"revision\":2,\"provenance\":\"mixed\"}"
}
}